Why GLP-1 Peptides Can Cause Depression – And How to Combat It

The Hunter Williams Podcast

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In this video, I explore why some people report experiencing depression while using GLP-1 peptides like semaglutide. Although I’ve had a positive experience with GLP-1s, I’ve heard from many who haven’t. So, I dive deep into potential reasons behind this phenomenon, including gut-brain axis disruption, neurotransmitter imbalances, and rapid weight loss. I also share solutions to help mitigate these effects. If you’ve felt low on GLP-1s or are considering using them, this video is for you. Let’s break down how to use these peptides to enhance life without compromising mental health.
Timestamps:
0:00 – Introduction
1:02 – Common reports of depression on GLP-1 peptides
2:00 – My support for GLP-1s and personal experiences
4:58 – Gut-brain axis disruption: How it might contribute to depression
7:40 – Changes in appetite and emotional coping mechanisms
11:13 – Neurotransmitter imbalances and mineral depletion
14:47 – Thyroid downregulation from rapid weight loss
16:39 – Reproductive hormone downregulation
19:02 – Sleep disturbances on GLP-1 peptides
21:41 – Confronting reality without compulsive behaviors
25:21 – Conclusion and takeaways
Join me as we uncover the underlying factors and how to address them for a better GLP-1 experience.