Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses With Dr Smith

JAMAevidence JAMA Guide to Statistics and Methods

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You Can Visit All Seven Continents. But Should You? 26:46

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For many travelers, Antarctica is a bucket-list destination, a once-in-a-lifetime opportunity to touch all seven continents. In 2023, a record-breaking 100,000 tourists made the trip. But the journey begs a fundamental question: What do we risk by traveling to a place that is supposed to be uninhabited by humans? And as the climate warms, should we really be going to Antarctica in the first place? SHOW NOTES: Kara Weller: The Impossible Dilemma of a Polar Guide Marilyn Raphael: A twenty-first century structural change in Antarctica’s sea ice system Karl Watson: First Time in Antarctica Jeb Brooks : 7 Days in Antarctica (Journey to the South Pole) Metallica - Freeze 'Em All: Live in Antarctica Learn about your ad choices: dovetail.prx.org/ad-choices…

2 years ago 18:25

MP3•Laman utama episod

Roger J. Lewis, MD, PhD, discusses Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses with Valerie A. Smith, DrPH. Related Content:

Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials

36 episod

#Science #Fitness #Medicine #American Medical Association #JAMA Network

Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses With Dr Smith

JAMAevidence JAMA Guide to Statistics and Methods

44 subscribers

published 2 years ago

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MP3•Laman utama episod

Roger J. Lewis, MD, PhD, discusses Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses with Valerie A. Smith, DrPH. Related Content:

Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials

36 episod

#Science #Fitness #Medicine #American Medical Association #JAMA Network

Semua episod

1
Nonparametric Statistical Analysis With Dr Lachin 11:56

22 days ago11:56

11:56

John M. Lachin, ScD, Biostatistics Center, George Washington University, discusses Nonparametric Statistical Analysis with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Nonparametric Statistical Analysis

1
The Use of Historical Controls in Clinical Trials, With Dr Althouse 20:45

11 weeks ago20:45

20:45

Andrew D. Althouse, PhD, University of Pittsburgh School of Medicine discusses The Use of Historical Controls in Clinical Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: The Use of Historical Controls in Clinical Trials

1
Futility in Clinical Trials With Dr Wendelberger 15:10

20 weeks ago15:10

15:10

Barbara Wendelberger, PhD, Berry Consultants, discusses Futility in Clinical Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Futility in Clinical Trials

1
Interim Analyses During Group Sequential Trials With Dr Meurer 16:14

24 weeks ago16:14

16:14

William J. Meurer, MD, MS, University of Michigan Medical School, discusses Interim Analyses During Group Sequential Trials with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Interim Analyses During Group Sequential Clinical Trials

1
Genome-Wide Association Studies With Dr Rotter 23:26

33 weeks ago23:26

23:26

Jerome I. Rotter, MD, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Department of Pediatrics, Harbor-UCLA Medical Center, discusses Genome-Wide Association Studies with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Genome-Wide Association Studies…

1
Conditional Power: How Likely Is Trial Success? 16:28

38 weeks ago16:28

16:28

Benjamin R. Saville, PhD, president and lead statistical scientist of Adaptix Trials, LLC and adjoint associate professor of biostatistics at Vanderbilt University Medical Center, discusses Conditional Power: How Likely Is Trial Success? with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Conditional Power…

1
Bayesian Hierarchical Models With Dr McGlothlin 15:07

42 weeks ago15:07

15:07

Anna E. McGlothlin, PhD, Berry Consultants, LLC, discusses Bayesian Hierarchical Models with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Bayesian Hierarchical Models

1
Sequential, Multiple Assignment, Randomized Trial Designs With Dr Kidwell 13:27

46 weeks ago13:27

13:27

Kelley Kidwell, PhD, professor of biostatistics, University of Michigan, discusses Sequential, Multiple Assignment, Randomized Trial Designs with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Sequential, Multiple Assignment, Randomized Trial Designs

1
Target Trial Emulation for Causal Inference From Observational Data With Dr Hernán 27:25

51 weeks ago27:25

27:25

Miguel A. Hernán, MD, DrPH, professor of epidemiology, Harvard T.H. Chan School of Public Health, discusses Target Trial Emulation: A Framework for Causal Inference From Observational Data with JAMA Statistical Editor Roger J. Lewis, MD, PhD. Related Content: Target Trial Emulation

1
On Deep Learning for Medical Image Analysis With Dr Carin 22:54

1 year ago22:54

22:54

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses On Deep Learning for Medical Image Analysis with Lawrence Carin, PhD. Related Content: On Deep Learning for Medical Image Analysis

1
Patient-Reported Outcome Measures in Clinical Research With Drs Weinfurt and Reeve 22:10

1 year ago22:10

22:10

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Patient-Reported Outcome Measures in Clinical Research with Kevin P. Weinfurt, PhD, and Bryce B. Reeve, PhD. Related Content: Patient-Reported Outcome Measures in Clinical Research

1
Immortal Time Bias in Observational Studies With Dr Kabir Yadav 15:06

1 year ago15:06

15:06

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Immortal Time Bias in Observational Studies with Kabir Yadav, MDCM, MS, MSHS. Related Content: Immortal Time Bias in Observational Studies

1
Adjustment for Baseline Characteristics in Randomized Clinical Trials 18:15

1 year ago18:15

18:15

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Adjustment for Baseline Characteristics in Randomized Clinical Trial with Lars W. Andersen, MD, MPH, PhD, DMSc. Related Content: Adjustment for Baseline Characteristics in Randomized Clinical Trials

1
Odds Ratios—Current Best Practice and Use With Dr Norton 12:19

1 year ago12:19

12:19

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Odds Ratios—Current Best Practice and Use with Edward C. Norton, PhD. Related Content: Odds Ratios—Current Best Practice and Use Types and Distribution of Payments From Industry to Physicians in 2015

1
Estimands, Estimators, and Estimates With Dr Little 22:06

2 years ago22:06

22:06

Roger J. Lewis, MD, PhD, discusses Estimands, Estimators, and Estimates with Roderick J. Little, PhD, in the JAMA Guide to Statistics and Methods series. Related Content: Estimands, Estimators, and Estimates

JAMAevidence JAMA Guide to Statistics and Methods

1
Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses With Dr Smith 18:25

2 years ago18:25

18:25

Roger J. Lewis, MD, PhD, discusses Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses with Valerie A. Smith, DrPH. Related Content: Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials

JAMAevidence JAMA Guide to Statistics and Methods

1
Time-to-Event Analysis With Dr Tolles 11:19

2 years ago11:19

11:19

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Time-to-Event Analysis with Juliana Tolles, MD, MHS. Related Content: Time-to-Event Analysis

JAMAevidence JAMA Guide to Statistics and Methods

1
Adjusting for Nonadherence or Stopping Treatments With Drs Adler and Latimer 17:58

2 years ago17:58

17:58

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Adjusting for Nonadherence or Stopping Treatments with Amanda I. Adler, MD, PhD, and Nicholas Latimer, PhD. Related Content: Adjusting for Nonadherence or Stopping Treatments in Randomized Clinical Trials

JAMAevidence JAMA Guide to Statistics and Methods

1
Worst-Rank Score Methods—A Nonparametric Approach to Informatively Missing Data With Dr Lachin 17:06

2 years ago17:06

17:06

JAMA Statistical Editor Roger J. Lewis, MD, PhD, discusses Worst-Rank Score Methods—A Nonparametric Approach to Informatively Missing Data with John M. Lachin, ScD. Related Content: Worst-Rank Score Methods—A Nonparametric Approach to Informatively Missing Data

JAMAevidence JAMA Guide to Statistics and Methods

1
Using Latent Class Analysis to Identify Hidden Clinical Phenotypes With Dr Heather G. Allore 17:34

3 years ago17:34

17:34

JAMA Statistical Editor Roger Lewis, MD, PhD, discusses Using Latent Class Analysis to Identify Hidden Clinical Phenotypes with Heather G. Allore, PhD. Related Content:

JAMAevidence JAMA Guide to Statistics and Methods

1
Use of Run-in Periods in Randomized Trials With Dr Armitage 19:29

3 years ago19:29

19:29

JAMA Statistical Editor Roger Lewis, MD, PhD, discusses Use of Run-in Periods in Randomized Trials with Jane M. Armitage, MBBS. Related Content: Use of Run-in Periods in Randomized Trials With Dr Armitage Short- and Long-term Effects of a Mobile Phone App in Conjunction With Brief In-Person Counseling on Physical Activity Among Physically Inactive Women: The mPED Randomized Clinical Trial…

JAMAevidence JAMA Guide to Statistics and Methods

1
Regression Discontinuity Study Design to Estimate Observational Differences With Dr Maciejewski 17:54

3 years ago17:54

17:54

JAMA Statistical Editor Roger Lewis, MD, discusses Regression Discontinuity Design with Matthew L. Maciejewski, PhD. Related Content: Regression Discontinuity Design Using Instrumental Variables to Address Bias From Unobserved Confounders

JAMAevidence JAMA Guide to Statistics and Methods

1
Case-Control Studies: Using “Real-world” Evidence to Assess Association, With Dr Irony 23:07

3 years ago23:07

23:07

JAMA Statistical Editor Roger Lewis, MD, discusses Case-Control Studies: Using “Real-world” Evidence to Assess Association, With Dr Irony .

JAMAevidence JAMA Guide to Statistics and Methods

1
Equipoise in Research—Integrating Ethics and Science in Human Research 21:48

4 years ago21:48

21:48

Roger J. Lewis, MD, PhD, discusses Equipoise in Research—Integrating Ethics and Science in Human Research with Alex John London, PhD Related Content: Equipoise in Research—Integrating Ethics and Science in Human Research

JAMAevidence JAMA Guide to Statistics and Methods

1
Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials 27:31

4 years ago27:31

27:31

Roger J. Lewis, MD, PhD, discusses Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials with Melanie Quintana, PhD Related Content: Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial Incorporating Adult Evidence Into Pediatric Research and Practice: Bayesian Designs to Expedite Obtaining Child-Specific Evidence…

JAMAevidence JAMA Guide to Statistics and Methods

1
Cost-effectiveness Analysis for Clinicians 18:21

4 years ago18:21

18:21

Cost-effectiveness analysis defines trade-offs between costs, harms, and benefits of alternative treatments and combines them into a single metric, the incremental cost-effectiveness ratio (ICER), that can inform decisions about which interventions to recommend when limited resources are available. Gillian Sanders-Schmidler, PhD, professor of population health sciences and medicine at Duke University, explains the method in terms clinicians can understand. Related Article: Cost-effectiveness Analysis for Clinicians…

JAMAevidence JAMA Guide to Statistics and Methods

1
Multiple Comparison Procedures from the JAMA Guide to Statistics and Methods 22:47

4 years ago22:47

22:47

JAMA Deputy Editor Edward Livingston, MD, discusses " Multiple Comparison Procedures " with Dr. Jing Cao, PhD

JAMAevidence JAMA Guide to Statistics and Methods

1
Logistic Regression—What It Is and How to Use It in Clinical Research 32:47

4 years ago32:47

32:47

Logistic regression is one of the most commonly used statistical analytic tools in the medical literature. William Meurer, MD, from the University of Michigan, and Juliana Tolles, MD, from UCLA, discuss a JAMA Guide to Statistics and Methods article they wrote entitled “Logistic Regression Diagnostics: Understanding How Well a Model Predicts Outcomes.” Related Article: Logistic Regression…

JAMAevidence JAMA Guide to Statistics and Methods

1
Randomization in Clinical Trials from the JAMA Guide to Statistics and Methods 23:14

4 years ago23:14

23:14

Roger J. Lewis, MD, PhD, discusses Randomization in Clinical Trials from the JAMA Guide to Statistics and Methods Related Article(s): Randomization in Clinical Trials

JAMAevidence JAMA Guide to Statistics and Methods

1
The Stepped-Wedge Clinical Trial: Evaluation by Rolling Deployment 18:07

5 years ago18:07

18:07

Cluster randomized trials are performed when an intervention must be delivered to a group of patients like when testing new nursing protocols on award or different means for cleaning beds on a ward. One type of cluster trials is called a stepped-wedge where every cluster in the study ultimately undergoes the intervention. How this works it is explained by Susan Ellenberg, PhD, from the Department of Biostatistics, Epidemiology, and Informatics at the University of Pennsylvania School of Medicine. Related Article: The Stepped-Wedge Clinical Trial…

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Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses With Dr Smith