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David Rubinsztein: Autophagy 2.0: An Anecdote for Poisonous Proteins in Neurodegenerative Disorders
Manage episode 407153287 series 3558288
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Accumulation of toxic proteins in neurons that wither and die is a fundamental problem in neurodegenerative disorders - Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia, ALS, and Huntington’s disease. In this episode Professor David Rubinsztein at the University of Cambridge talks about how impaired autophagy results in the accumulation of the toxic proteins. Aging, and genetic and environmental factors may impair autophagy and thereby result in neurodegenerative disease. Neuroscientists and neurologists are developing ways to stimulate autophagy and thereby prevent the accumulation of toxic proteins.
LINKS:
Professor Rubinsztein’s lab page:
https://www.cimr.cam.ac.uk/staff/professor-david-rubinsztein-fmedsci-frs
Review on autophagy in neurodegenerative disorders:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930707/pdf/nihms-1771452.pdf
Article on removing toxic proteins in neurodegenerative disorders:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456907/pdf/nihms-1007879.pdf
Impaired autophagy and amyloid accumulation in Alzheimer’s disease:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174056/pdf/41593_2022_Article_1084.pdf
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