14. Early Life Trauma and Opioid Use Disorder

Addiction Medicine Journal Club

In episode 14 we discuss the connection between early life trauma, depression, anxiety, stress, and opioid use disorder.

Effects of Early Life Trauma on Risks for Adult Opioid Use Disorder Are Mediated by Stress and Occur Independent of Depression and Anxiety. Dunn, Kelly E. PhD, MBA; Turner, Gavin M. BS; Oswald, Lynn M. PhD. Journal of Addiction Medicine: 11/12 2022 - Volume 16 - Issue 6 - p 709-715 doi: 10.1097/ADM.0000000000001011

We also discuss an opinion piece on AMA discharges and the new fentanyl vaccine.

Retiring the “Against Medical Advice” Discharge Robert A. Kleinman, Thomas D. Brothers, Nathaniel P. Morris. Ann Intern Med.2022;175:1761-1762. [Epub 29 November 2022]. doi:10.7326/M22-2964

An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats Haile CN, Baker MD, Sanchez SA, Lopez Arteaga CA, Duddupudi AL, Cuny GD, Norton EB, Kosten TR, Kosten TA. Pharmaceutics. 2022; 14(11):2290.

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Episode 14 Credits:

• Original theme music: composed and performed by Benjamin Kennedy
• Audio production: Angela Ohlfest

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This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.

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Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.