Artificial Intelligence has suddenly gone from the fringes of science to being everywhere. So how did we get here? And where's this all heading? In this new series of Science Friction, we're finding out.
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EP 168: A world-first in RNA medicines with Erik Ingelsson, Chief Scientific Officer at Wave Life Sciences
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Kandungan disediakan oleh Sano Genetics. Semua kandungan podcast termasuk episod, grafik dan perihalan podcast dimuat naik dan disediakan terus oleh Sano Genetics atau rakan kongsi platform podcast mereka. Jika anda percaya seseorang menggunakan karya berhak cipta anda tanpa kebenaran anda, anda boleh mengikuti proses yang digariskan di sini https://ms.player.fm/legal.
0:00 Intro to The Genetics Podcast
01:00 Welcome to Erik
02:05 Key differences between DNA and RNA editing
05:25 Wave’s recent world-first finding in Alpha-1 Antitrypsin Deficiency
08:17 Dosage regularity and delivery process for edited RNA therapies
14:08 Next steps for Wave’s new discovery, including potential applications in other conditions
17:41 Using genetic targets to inform areas of focus and RNA treatment development
24:04 The GLP1 mechanism in human genetics and its role in obesity
25:43 Erik’s transition from big pharma to biotech and the resulting changes in his approach to treatment development
31:02 What has driven Erik to explore and experience a wide range of roles throughout his career
34:29 The importance of balancing fatherhood with a thriving career, and how Erik works to do so successfully
38:35 Closing remarks
Find out more
Please consider rating and reviewing us on your chosen podcast listening platform!
199 episod
MP3•Laman utama episod
Manage episode 458944960 series 2631947
Kandungan disediakan oleh Sano Genetics. Semua kandungan podcast termasuk episod, grafik dan perihalan podcast dimuat naik dan disediakan terus oleh Sano Genetics atau rakan kongsi platform podcast mereka. Jika anda percaya seseorang menggunakan karya berhak cipta anda tanpa kebenaran anda, anda boleh mengikuti proses yang digariskan di sini https://ms.player.fm/legal.
0:00 Intro to The Genetics Podcast
01:00 Welcome to Erik
02:05 Key differences between DNA and RNA editing
05:25 Wave’s recent world-first finding in Alpha-1 Antitrypsin Deficiency
08:17 Dosage regularity and delivery process for edited RNA therapies
14:08 Next steps for Wave’s new discovery, including potential applications in other conditions
17:41 Using genetic targets to inform areas of focus and RNA treatment development
24:04 The GLP1 mechanism in human genetics and its role in obesity
25:43 Erik’s transition from big pharma to biotech and the resulting changes in his approach to treatment development
31:02 What has driven Erik to explore and experience a wide range of roles throughout his career
34:29 The importance of balancing fatherhood with a thriving career, and how Erik works to do so successfully
38:35 Closing remarks
Find out more
Please consider rating and reviewing us on your chosen podcast listening platform!
199 episod
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