Ep. 82: Taking PrEP to the Next Level

Sounds of Science

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Biotech

Pharmacology

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Mind The Business: Small Business Success Stories

1
Pushing Past Stagnation & Business Plateaus 30:21

8 days ago30:21

Main Kemudian

Senarai

Suka

Disukai

30:21

Hitting plateaus is a common milestone in business, but there’s a difference between stability and a rut. In the last installment of this season, we’ll dive into the ways small business owners push beyond plateaus and find new ways to achieve revenue growth. Jannese and Austin wrap up their time in Nashville, Tennessee with a wonderful visit to N.B. Goods to speak with owner Camille Alston . Camille details the times where she hit a wall with profits, the strategies she implemented to increase revenue, what worked, what didn’t, and the important lessons she learned in the process. You won’t want to miss this informative final chapter! Learn more about how QuickBooks can help you grow your business: QuickBooks.com See omnystudio.com/listener for privacy information.…

about a year ago 29:11

MP3•Laman utama episod

Dr. Jared Baeten, Senior Vice President of Clinical Development and Virology Therapeutic Area Head at Gilead Sciences, joins me to discuss the incredible advancements in pre-exposure prophylaxis (PrEP) treatments in honor of World AIDS Day. What if a twice yearly shot could replace a daily pill? Listen now to learn more!

92 episod

#Tech #Drugdiscovery #Pharmaceutical #Research #Charles River #Biotech #Science #Natural Sciences #Pharmacology #Medicine #Sounds Of Science

Sounds of Science

Ep. 82: Taking PrEP to the Next Level

Sounds of Science

66 subscribers

published about a year ago

Kongsi

MP3•Laman utama episod

92 episod

#Tech #Drugdiscovery #Pharmaceutical #Research #Charles River #Biotech #Science #Natural Sciences #Pharmacology #Medicine #Sounds Of Science

Semua episod

Sounds of Science

1
Evolving Animal Welfare: Science, Ethics, and Innovation 30:03

10 days ago30:03

30:03

Are we on the brink of a major shift in research? In this episode of Sounds of Science , Charles River experts challenge traditional approaches, exploring cutting-edge innovations that enhance animal welfare while driving scientific breakthroughs. From revolutionary non-animal testing methods to advanced behavioral management strategies, we uncover how ethical care leads to better data and faster drug discovery. Tune in to discover how science, compassion, and innovation are shaping the next era of drug development. Show Notes Animals in Research | 3Rs Alternative Methods Advancement Project CHARTER Program for Lab Animal Welfare Advancing Responsible Science…

Sounds of Science

1
Cancer Vaccines, Then and Now 34:34

24 days ago34:34

34:34

Did you know that the first attempt at a cancer vaccine was all the way back in the 1800s? I am joined by Charles River experts Louise Brackenbury, Dan Rocca, and Mike Templin to discuss the fascinating science behind therapeutic cancer vaccines. Clarification: Coley’s Toxin is not a vaccine in the traditional sense, but a compound developed by William Coley in the 19th century as a treatment for cancer, and is considered a precursor to modern cancer immunotherapy.…

Sounds of Science

1
All About Spheroids 26:54

5 weeks ago26:54

26:54

Spheroids are three dimensional cell models that can mimic some organs, tumors, and other biological systems for drug testing. Like organoids and organs-on-a-chip, spheroids are breaking in to drug development as a promising alternative to animal models. I am joined by Madhu Lal Nag, MBS PhD from the 3D in vitro model company InSphero, to discuss the development and future potential of these tiny cellular machines.…

Sounds of Science

1
Ep. 89: Rethinking Toxicology: The Future of NAMs in Agrochemicals 27:46

7 weeks ago27:46

27:46

The agrochemical field has long relied on animal models to evaluate the safety and efficacy of substances, but there’s a growing demand to adopt new alternative methods (NAMs) that can further the industry while reducing the need for animal testing. However, questions remain as to their long-term viability. Join Robert Landsiedel, Vice President of Experimental Toxicology and Ecology, and Susanne Kolle, Research Coordinator of Experimental Toxicology and Ecology at BASF, as they explain the benefits of NAMs, how they comply with the 3Rs principle, and the role collaboration is playing to push NAMs as a viable alternative to animals. Show Notes Alternative Methods AMAP Strategic Partnerships Animals in Research Modernizing Drug Development Agrochemical Testing Service for Approvals Chemical Testing Services Charles River Laboratories Announces Development of Nonclinical Virtual Control Groups with Sanofi to Reduce the Use of Animals Charles River Laboratories, in Collaboration with MatTek Corporation, Awarded Grant from the Foundation for Chemistry Research and Initiatives to Advance Research Alternatives…

Sounds of Science

1
Ep. 88: The Epidemiology of Cancer 31:29

9 weeks ago31:29

31:29

How can genetic, geographic, and social considerations effect outcomes for Black women with cancer? To answer this question, I am joined this week by Dr. Lauren E. McCullough, Associate Professor in the Department of Epidemiology at the Rollins School of Public Health, and Julia Schueler, Research Director Therapeutic Area Lead Oncology for Charles River. Dr. McCullough is also one of the lead researchers for the American Cancer Society’s VOICES of Black Women initiative, which will track the health of participants over several years to gain insight into health considerations for Black women. For more information on how to enroll, please visit voices.cancer.org .…

Sounds of Science

1
Ep. 87: Taking a Customized and Collaborative Approach to Therapeutic Development 28:49

11 weeks ago28:49

28:49

The N=1 Collaborative is changing the way we view drug development. Their specialty is creating customized therapies tailored to individual patients, paving the way for a unique approach that can leave long-lasting impacts on those with ultra-rare diseases. Join us as Executive Director Hugh Hempel discusses the origins of N=1, the collaborative effort it takes to advance customized therapies down the pipeline, and what the future holds for the field of individualized medicine. Show Notes n=1 Collaborative Rare Disease | Charles River Rare Disease Research for Drug Development Repurposing Drugs for Rare Disease S4 E07: Free For Life: The Story of N-Lorem Foundation…

Sounds of Science

1
Ep. 85: The Next Generation of Drug Development 26:01

13 weeks ago26:01

26:01

Artificial intelligence and machine learning are launching a new era in drug development. By integrating these technologies, researchers can get their life-saving therapies to patients faster thanks to more accurate data and efficient processes. Join us as Brian Roche, General Manager of Charles River’s integrated toxicology site in Kansas, as he discusses the advantages of using these advanced technologies, how their being leveraged across multiple platforms, and what role they play in shaping the future. Show Notes New Integrated Toxicology Site Kansas Site Unlocking the Promise of Integrated Toxicology: A Tour Through the Lab of the Future Meeting at the Intersection of Technology and Scientific Innovation…

Sounds of Science

1
Ep. 84: A Family's Fight Against Batten Disease 34:04

15 weeks ago34:04

34:04

David and Karen Kahn were overjoyed when they welcomed twins Amelia and Makenzie in 2010. However, it wasn't long before they realized their girls were different. Since getting their Batten disease diagnosis, they have worked tirelessly to find a treatment not only for their girls, but for kids around the world, with the help of researcher Dr. Michelle Hastings. Listen to their story now, and learn more about their mission at www.forebatten.org.…

Sounds of Science

1
Ep. 83: NAMs: The Future of Research? 24:31

18 weeks ago24:31

24:31

As researchers look for ways to reduce the need for animals in their studies, new alternative methods (NAMs) are an intriguing route to capture crucial safety data and help advance drug discovery and development – specifically, virtual control groups (VCGs). Join Steve Bulera, CVP and Chief Scientific Officer for Safety Assessment and Toxicology at Charles River, as he discusses how VCGs can be a viable alternative to research models, what it would take for the industry to widely accept NAMs, and how they can revolutionize research for the future. Show Notes Virtual Control Groups Sounds of Science E73: Virtual Control Groups Modernizing Drug Development with Virtual Control Groups Virtual Control Groups: A Data-Driven Novel Method Revolutionizing the Future of Safety Studies Charles River Laboratories Announces Development of Nonclinical Virtual Control Groups with Sanofi to Reduce the Use of Animals…

Sounds of Science

31 weeks ago1:01:34

1:01:34

Imagine you’re exploring the great outdoors when, out of nowhere, you feel the fangs of a snake – a poisonous snake – breaking through your skin. Medical care is nowhere in sight, so you’re left with the terrifying prospect of venom slowly infecting your body’s critical functions. This is the reality that roughly five million people face annually. Over 500,000 of which either die or are permanently maimed or suffer long-term cardiovascular/neurological impairments. However, Drs. Rebecca Carter and Matt Lewin are working to change that. Their work at Ophirex revolves around further developing Varespladib, a repurposed drug, as an accessible and affordable oral treatment to instantly combat venomous snakebites. By ingesting a small tablet or capsule, victims can buy time to seek out more advanced care, giving them a better chance to limit complications and prevent death. Join us as we explore the impacts snake venom has on the body, how Drs. Carter and Lewin discovered Varespladib, how collaborations and partnerships have benefited their development of this treatment, and what can be done to improve its accessibility, especially in remote areas of the world. Show Notes Ophirex Lifesaving Antidotes Antivenoms -_World Health Organization Interventions for the Preventing Reactions to Snake Venoms - National Institute of Health…

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