303 | James P. Allison on Fighting Cancer with the Immune System

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

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<div class="span index">1</div> <span><a class="" data-remote="true" data-type="html" href="/series/standup-comedy-your-host-and-mc">Standup Comedy "Your Host and MC"</a></span>

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Standup Comedy "Your Host and MC"

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Celebration of 40+ years on the fringe of show business. Stories, interviews, and comedy sets from standup comics... famous, and not so famous. All taped Live on my Comedy stage. The interviews will be with comics, old staff members, and Friends from the world of Comedy. Standup Sets by Dana Carvey, Jay Leno, Tom Dreesen, Jerry Seinfeld, Larry Miller, Mark Schiff, Bobcat Goldthwait, Paula Poundstone, Garry Shandling, Ray Ramano, Cathy Ladman, Willie Tyler & Lester, and MORE. My web site has many pictures, items for sale, and more information www.standupcomedyyourhostandmc.com

about a year ago 1:07:38

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/27/303-james-p-allison-on-fighting-cancer-with-the-immune-system/

James P. Allison received his Ph.D. in biology from the University of Texas at Austin. He is currently Regental Professor and Chair of the Department of Immunology, the Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, and Director of the James P. Allison Institute at MD Anderson Cancer Center. He is the subject of the documentary film Jim Allison: Breakthrough. Among his numerous awards are the Breakthrough Prize in Life Sciences and the Nobel Prize in Physiology or Medicine.

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378 episod

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Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

303 | James P. Allison on Fighting Cancer with the Immune System

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

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Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
307 | Kevin Peterson on the Theory of Cocktails 1:16:36

7 days ago1:16:36

1:16:36

A lot of science goes into crafting the perfect cocktail. Balancing sweet and bitter notes, providing the right amount of aeration and dilution, getting it to just the right temperature and keeping it that way. And even if you have no interest in cocktails as such, the general principles extend to other activities in art and in life. I talk to scientist-turned-mixologist Kevin Peterson about how to think about the simple magic of a perfect drink. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/03/03/307-kevin-peterson-on-the-theory-of-cocktails/ S upport Mindscape on Patreon . Kevin Peterson received a Ph.D. in Mechanical Engineering from the University of Michigan. He is currently co-owner of both Castalia (an experimental craft cocktail bar) and Sfumato Fragrances in Detroit, Michigan. He is the author of Cocktail Theory: A Sensory Approach to Transcendent Cocktails . Mindscape Petrichor Negroni (from the episode) 1 part gin distilled from vetiver (alternative: herbaceous gin such as Moletto ) 1 part St. George Bruto Americano 1 part Antica Formula vermouth Stir over an ice cube, express with orange peel (not shown). See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
306 | Helen Czerski on Our Energetic Oceans 1:12:19

13 days ago1:12:19

1:12:19

It is commonplace to refer to the Earth's oceans as vast and largely unexplored. But we do understand some aspects, and improving that understanding is crucial to ensuring the continued viability and success of life on this planet. The oceans are a paradigmatic complex system: there are many components, distinct but mutually interacting, that add up to a nuanced whole. We talk with ocean physicist Helen Czerski about what the ocean is and how it's changing. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/24/306-helen-czerski-on-our-energetic-oceans/ S upport Mindscape on Patreon . Helen Czerski received her Ph.D. in physics from the University of Cambridge. She is currently an Associate Professor at the Department of Mechanical Engineering at University College London. She is the author of several books, most recently The Blue Machine: How the Ocean Works . She is a frequent television presenter for the BBC and elsewhere. Web site UCL web page Google Scholar publications Wikipedia Amazon author page Bluesky See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
305 | Lilliana Mason on Polarization and Political Psychology 1:17:25

21 days ago1:17:25

1:17:25

Political outcomes would be relatively simple to predict and understand if only people were well-informed, entirely rational, and perfectly self-interested. Alas, real human beings are messy, emotional, imperfect creatures, so a successful theory of politics has to account for these features. One phenomenon that has grown in recent years is an alignment of cultural differences with political ones, so that polarization becomes more entrenched and even violent. I talk with political scientist Lilliana Mason about how this has come to pass, and how democracy can deal with it. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/17/305-lilliana-mason-on-polarization-and-political-psychology/ Support Mindscape on Patreon . Lilliana Hall Mason received her Ph.D. in political psychology from Stony Brook University. She is currently an SNF Agora Institute Associate Professor of Political Science at Johns Hopkins University. She is the author of Uncivil Agreement: How Politics Became Our Identity and co-author (with Nathan Kalmoe) of Radical American Partisanship: Mapping Violent Hostility, Its Causes, and the Consequences for Democracy . Web Site Hopkins web page Google Scholar publications Bluesky See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
Bonus | Cuts to Science Funding and Why They Matter 1:10:25

25 days ago1:10:25

1:10:25

The Trump administration, led by Elon Musk and his Department of Government Efficiency, has proposed sweeping cuts to spending on science research here in the US, in particular at the National Institutes of Health and the National Science Foundation. I explain a little about what is being cut and why these funds are important to scientific progress. I try, for what it's worth, to provide these explanations in a way that would be informative to those who generally favor cutting government waste in dramatic fashion. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/12/bonus-cuts-to-science-funding-and-why-they-matter/ S upport Mindscape on Patreon . Indirect costs primer Cuts to NIH indirect costs Appropriated funds are mandated by statute Proposed NSF cuts Elon Musk doesn't understand indirect costs Shrimp treadmill story Bribing foreign officials Deleting NSA web pages Executive Orders are not laws History of impoundments See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
304 | James Evans on Innovation, Consolidation, and the Science of Science 1:16:03

27 days ago1:16:03

1:16:03

It is a feature of many human activities - sports, cooking, music, interpersonal relations - that being able to do them well doesn't necessarily mean you can accurately describe how to do them well. Science is no different. Many successful scientists are not very good at explaining what goes into successful scientific practice. To understand that, it's necessary to study science in a scientific fashion. What kinds of scientists, in what kinds of collaborations, using what kinds of techniques, do well? I talk with James Evans, an expert on collective intelligence and the construction of knowledge, about how science really works. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/02/10/304-james-evans-on-innovation-consolidation-and-the-science-of-science/ S upport Mindscape on Patreon . James Evans received his Ph.D. in Sociology from Stanford University. He is currently the Max Palevsky Professor of History and Civilizations, Director of Knowledge Lab, and Faculty Director of Computational Social Science at the University of Chicago; External Professor at the Santa Fe Institute; External Faculty at the Complexity Science Hub, Vienna; and Visiting Faculty Researcher at Google. Knowledge Lab web site University of Chicago web page Google scholar publications See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

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303 | AMA | February 2025 3:44:12

5 weeks ago3:44:12

3:44:12

Welcome to the February 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with questions and transcript: https://www.preposterousuniverse.com/podcast/2025/02/03/ama-february-2025/ S upport Mindscape on Patreon . See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
303 | James P. Allison on Fighting Cancer with the Immune System 1:07:38

6 weeks ago1:07:38

1:07:38

A typical human lifespan is approximately three billion heartbeats in duration. Lasting that long requires not only intrinsic stability, but an impressive capacity for self-repair. Nevertheless, things do occasionally break down, and cancer is one of the most dramatic examples of such breakdown. Given that the body is generally so good at protecting itself, can we harness our internal security patrol - the immune system - to fight cancer? This is the hope of Nobel Laureate James Allison, who works on studying the structure and behavior of immune cells, and ways to coax them into fighting cancer. This approach offers hope of a way to combat cancer effectively, lastingly, and in a relatively gentle way. Support Mindscape on Patreon . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/27/303-james-p-allison-on-fighting-cancer-with-the-immune-system/ James P. Allison received his Ph.D. in biology from the University of Texas at Austin. He is currently Regental Professor and Chair of the Department of Immunology, the Olga Keith Wiess Distinguished University Chair for Cancer Research, Director of the Parker Institute for Cancer Research, and Director of the James P. Allison Institute at MD Anderson Cancer Center. He is the subject of the documentary film Jim Allison: Breakthrough . Among his numerous awards are the Breakthrough Prize in Life Sciences and the Nobel Prize in Physiology or Medicine. Web page Nobel Prize citation Google Scholar publications Wikipedia See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

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302 | Chris Kempes on the Biophysics of Evolution 1:30:54

7 weeks ago1:30:54

1:30:54

Randomness plays an important role in the evolution of life (as my evil twin will tell you). But random doesn't mean arbitrary. Biological organisms are physical objects, after all, and subject to the same laws of physics as non-biological matter is. Those laws place constraints on how organisms can fulfill their basic functions of metabolism, reproduction, motility, and so on. Easy to say, but how can we turn this into quantitative understanding of actual organisms? Today I talk with physical biologist Chris Kempes about how physics can help us understand the size of organisms, their metabolisms, and features of major transitions in evolution. S upport Mindscape on Patreon . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/20/302-chris-kempes-on-the-biophysics-of-evolution/ Chris Kempes received his Ph.D. in physical biology from the Massachusetts Institute of Technology. He is currently Professor and a member of the Science Steering Committee at the Santa Fe Institute. His research involves the origin of life and the constraints placed by physics on biological function and evolution. Web site Santa Fe Institute web page Google Scholar publications Origins of Life online course See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
301 | Tina Eliassi-Rad on Al, Networks, and Epistemic Instability 1:09:21

8 weeks ago1:09:21

1:09:21

Big data is ruling, or at least deeply infiltrating, all of modern existence. Unprecedented capacity for collecting and analyzing large amounts of data have given us a new generation of artificial intelligence models, but also everything from medical procedures to recommendation systems that guide our purchases and romantic lives. I talk with computer scientist Tina Elassi-Rad about how we can sift through all this data, make sure it is deployed in ways that align with our values, and how to deal with the political and social dangers associated with systems that are not always guided by the truth. S upport Mindscape on Patreon . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/13/301-tina-eliassi-rad-on-al-networks-and-epistemic-instability/ Tina Eliassi-Rad received her Ph.D. in computer science from the University of Wisconsin-Madison. She is currently Joseph E. Aoun Chair of Computer Sciences and Core Faculty of the Network Science Institute at Northeastern University, External Faculty at the Santa Fe Institute, and External Faculty at the Vermont Complex Systems Center. She is a fellow of the Network Science Society, recipient of the Lagrange Prize, and was named one of the 100 Brilliant Women in AI Ethics. Web site Northeastern web page Google Scholar publications Wikipedia See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
300 | Solo: Does Time Exist? 2:11:35

9 weeks ago2:11:35

2:11:35

A new year, and a new centennial -- 300 (regularly-numbered) episodes of Mindscape! Our tradition is to have a solo episode, and what better topic than the nature of time? Physicists and philosophers have so frequently suggested that time is some kind of illusion that it's become almost passé to believe that it might be fundamental. This is an issue where, despite the form of the question, physics has important things to say that most philosophers haven't yet caught up to. I will talk about ideas from quantum mechanics and quantum gravity that bear on the question of whether time is emergent or fundamental, and the implications of each possibility. S upport Mindscape on Patreon . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2025/01/06/300-solo-does-time-exist/ Some of the papers discussed herein: Carroll (2008), " What If Time Really Exists? " Dyson, Kleban, and Susskind (2002), " Disturbing Implications of a Cosmological Constant ." Albrecht and Sorbo (2004), " Can the Universe Afford Inflation? " Boddy, Carroll, and Pollack (2014), " De Sitter Space Without Dynamical Quantum Fluctuations ." Lloyd (2016), " Decoherent Histories Approach to the Cosmological Measure Problem ." Page and Wootters (1983), " Evolution Without Evolution: Dynamics Described by Stationary Observables ." Albrecht (1994), " The Theory of Everything vs the Theory of Anything ." Albrecht and Iglesias (2007), " The Clock Ambiguity and the Emergence of Physical Laws ." See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
Holiday Message | Hits and Misses 2:01:23

11 weeks ago2:01:23

2:01:23

It's the end of the year, and time for our annual holiday break here at Mindscape. But as usual, we wrap up with a Holiday Message. This year, inspired by Joni Mitchell's "Hits" and "Misses" albums, I go through my scientific papers and talk about some of my favorites -- some of which were hits, in terms of making an impact on subsequent research, and some of which were misses by that standard. But I love them all! It's an excuse to talk about process -- how papers come to be, from the initial informal idea to sitting down and doing the work. S upport Mindscape on Patreon . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/23/holiday-message-hits-and-misses/ Here are links to the papers I discuss in the episode. S.M. Carroll, G.B. Field and R. Jackiw, 1990, "Limits on A Lorentz and Parity-Violating Modification of Electrodynamics,'' Phys. Rev. D 41 , 1231. [ pdf file ; inSPIRE ] S.M. Carroll, E. Farhi and A.H. Guth, 1992, "An Obstacle to Building a Time Machine,'' Phys. Rev. Lett. 68 , 263; Erratum: 68 , 3368. [ pdf file ; inSPIRE ] S.M. Carroll, E. Farhi, A.H. Guth and K.D. Olum, 1994, "Energy-Momentum Restrictions on the Creation of Gott Time Machines,'' Phys. Rev. D 50 , 6190; gr-qc/9404065. [ arXiv ; pdf ; inSPIRE ] S.M. Carroll, 1998, "Quintessence and the Rest of the World,'' Phys. Rev. Lett. 81 , 3067; astro-ph/9806099. [ arXiv ; pdf ; inSPIRE ] S.M. Carroll, V. Duvvuri, M. Trodden, and M.S. Turner, 2003, "Is Cosmic Speed-Up Due to New Gravitational Physics?'' astro-ph/0306438. [ arXiv ; pdf ; inSPIRE ] S.M. Carroll and J. Chen, 2004, "Spontaneous Inflation and the Origin of the Arrow of Time'', hep-th/0410270. [ arXiv , inSPIRE ] L. Ackerman, M.R. Buckley, S.M. Carroll, and M. Kamionkowski, 2008, "Dark Matter and Dark Radiation," arxiv:0807.5126. [ arXiv ; pdf ; inSPIRE ] S.M. Carroll, M.C. Johnson, and L. Randall, 2009, "Dynamical Compactification," arxiv:0904.3115. [ arXiv ; pdf ; inSPIRE ] C. Cao, S.M. Carroll, and S. Michalakis, 2016, "Space from Hilbert Space: Recovering Geometry from Bulk Entanglement," arxiv:1606.08444. [ arXiv , inSPIRE ] C. Cao and S.M. Carroll, 2018, "Bulk Entanglement Gravity without a Boundary: Towards Finding Einstein's Equation in Hilbert Space," arxiv:1712.02803. [ arXiv , inSPIRE ] N. Bao, S.M. Carroll, A. Chatwin-Davies, J. Pollack, and G. Remmen, 2017, “Branches of the Black Hole Wave Function Need Not Contain Firewalls," arxiv:1712.04955. [ arXiv , inSPIRE ] See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
299 | Michael Wong on Information, Function, and the Origin of Life 1:13:00

12 weeks ago1:13:00

1:13:00

Living organisms seem exquisitely organized and complex, with features clearly adapted to serving certain functions needed to survive and procreate. Natural selection provides a compelling explanation for why that is so. But is there a bigger picture, a more general framework that explains the origin and evolution of functions and complexity in a world governed by uncaring laws of physics? I talk with planetary scientist and astrobiologist Michael Wong about how we can define what "functions" are and the role they play in the evolution of the universe. S upport Mindscape on Patreon . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/16/299-michael-wong-on-information-function-and-the-origin-of-life/ Michael Wong received his Ph.D. in planetary science from Caltech. He is currently a Sagan Postdoctoral Fellow at the Carnegie Institution for Scienceʼs Earth & Planets Laboratory. He is in the process of co-authoring two books: A Missing Law: Evolution, Information, and the Inevitability of Cosmic Complexity with Robert M. Hazen, and a revised edition of Astrobiology: A Multidisciplinary Approach with Jonathan Lunine. Web site Carnegie web page Strange New Worlds podcast Wong et al. (2023), " On the Roles of Function and Selection in Evolving Systems ." Wong and Prabhu (2023), " Cells as the First Data Scientists ." See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
298 | Jeff Lichtman on the Wiring Diagram of the Brain 1:09:09

13 weeks ago1:09:09

1:09:09

The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome : the complete map of those connections. For a human brain that's an intimidatingly complex challenge, but important advances have been made on tinier brains. We talk with Jeff Lichtman, a leader in brain mapping, to gauge the current state of progress and what it implies. Support Mindscape on Patreon . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/12/09/298-jeff-lichtman-on-the-wiring-diagram-of-the-brain/ Jeff Lichtman received an MD/PhD from Washington University in St. Louis. He is currently the Jeremy R. Knowles Professor of Molecular and Cellular Biology and Santiago Ramón y Cajal Professor of Arts and Sciences at Harvard University. He is co-inventor of the Brainbow system for imaging neurons. He is a member of the National Academy of Sciences. Web page Lab web site Google Scholar publications Wikipedia See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
AMA | December 2024 3:55:31

14 weeks ago3:55:31

3:55:31

Welcome to the December 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2024/12/02/ama-december-2024/ Support Mindscape on Patreon . See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

1
297 | Emily Wilson on Homer, Poetry, and Translation 1:15:12

15 weeks ago1:15:12

1:15:12

Not too long ago, Brad Pitt and Eric Bana starred in a (loose) adaptation of Homer's epic poem The Iliad ; next month, Ralph Fiennes and Juliette Binoche will headline a film based on The Odyssey . Given that the originals were written (or at least written down) in the 8th century BCE, that is some impressive staying power. But they were also written in a very different time than ours, with different cultural context and narrative expectations. We talk about the issues of translation in general, and these Greek classics in particular, with Emily Wilson, whose recent translations of The Iliad and The Odyssey have garnered worldwide acclaim. S upport Mindscape on Patreon . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2024/11/25/297-emily-wilson-on-homer-poetry-and-translation/ Emily Wilson received her Ph.D. in classical and comparative literature from Yale. She is currently Professor of Classical Studies at the University of Pennsylvania. Among her awards are the Charles Berheimer Prize from the American Comparative Literature Association, a Rome Prize fellowship from the American Academy in Rome, and Guggenheim and MacArthur fellowships. Web site UPenn web page Wikipedia Amazon.com author page YouTube Substack BlueSky See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

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303 | James P. Allison on Fighting Cancer with the Immune System