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Bio Bytes 31: The structure and functions of p53 with Carol Prives

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Manage episode 358364932 series 3145074
Kandungan disediakan oleh Columbia Sys Bio Initiative. Semua kandungan podcast termasuk episod, grafik dan perihalan podcast dimuat naik dan disediakan terus oleh Columbia Sys Bio Initiative atau rakan kongsi platform podcast mereka. Jika anda percaya seseorang menggunakan karya berhak cipta anda tanpa kebenaran anda, anda boleh mengikuti proses yang digariskan di sini https://ms.player.fm/legal.

Description: In which Sophia speaks with Carol Prives, the Da Costa Professor of Cell and Molecular Biology at Columbia University and a member of both the National Academy of Sciences and the American Academy of Arts and Sciences, about her journey researching the structure and function of the p53 tumor suppressor protein. She delves into the importance and regulation of p53, including its relationship with kinases, Mdm2, and the Mevalonate pathway.

Editorial Note: During the discussion regarding the mevalonate pathway, the listener should note that genes in this pathway had reduced expression when mutant p53 levels were reduced. Pathway genes, themselves, were not mutated.

  continue reading

38 episod

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iconKongsi
 
Manage episode 358364932 series 3145074
Kandungan disediakan oleh Columbia Sys Bio Initiative. Semua kandungan podcast termasuk episod, grafik dan perihalan podcast dimuat naik dan disediakan terus oleh Columbia Sys Bio Initiative atau rakan kongsi platform podcast mereka. Jika anda percaya seseorang menggunakan karya berhak cipta anda tanpa kebenaran anda, anda boleh mengikuti proses yang digariskan di sini https://ms.player.fm/legal.

Description: In which Sophia speaks with Carol Prives, the Da Costa Professor of Cell and Molecular Biology at Columbia University and a member of both the National Academy of Sciences and the American Academy of Arts and Sciences, about her journey researching the structure and function of the p53 tumor suppressor protein. She delves into the importance and regulation of p53, including its relationship with kinases, Mdm2, and the Mevalonate pathway.

Editorial Note: During the discussion regarding the mevalonate pathway, the listener should note that genes in this pathway had reduced expression when mutant p53 levels were reduced. Pathway genes, themselves, were not mutated.

  continue reading

38 episod

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