NEW RENAISSANCE IN HEALTHCARE - INNOVATION OLYMPICS SERIES EPISODE 1

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Rethinking Alzheimer's Disease Podcast

1
Ep 1: What Is Alzheimer’s Disease? 16:03

48 weeks ago16:03

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16:03

Learn about the differences between Alzheimer's and dementia, and how Alzheimer's disease progresses. We talk about why catching the disease early can make a big difference. Dr. Sharon Cohen and Dr. Yaakov Stern walk us through the stages of Alzheimer's disease, from when there are no symptoms to when memory issues start to show. They explain the stages of Alzheimer’s and how it develops over time. We also hear from Kelly, who explains her personal experiences and concerns about developing Alzheimer’s, and what she does about it. For links to resources and information covered in this series, visit our website at HealthUnmuted.com/resources What did you think of this episode? We’d love to hear from you. Please visit healthunmuted.com/feedback to let us know! Rethinking Alzheimer’s Disease was made possible with support from Eisai Inc. [00:00:00] Introduction [00:03:10] What's the difference between Alzheimer's disease and dementia? [00:07:04] When does Alzheimer’s begin to develop? [00:09:08] What is Mild Cognitive Impairment (MCI)? [00:10:36] What is subjective cognitive decline? [00:11:59] What is preclinical Alzheimer's disease? [00:13:13] Why is it important to detect Alzheimer’s disease early? Disclaimer: The content provided in this podcast is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast. Reliance on any information provided by this podcast or its guests is solely at your own risk. ©2024 Mission Based Media Ltd • April 2024 • AD-M2059…

about a year ago 15:10

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I am excited to kick off a new series of episodes on the Alloutcoach Podcast called "Innovation Olympics" which will capture some of the most memorable messages and lessons from the Opening Ceremony of the global annual ideation competition in which innovators in healthcare become "Olympians" for about 16 days and exchange their inspiration with sports Olympians, champions and coaches, patient advocates, and senior leaders across different industries. I host this industry-first Olympic-style innovation event on behalf of my company Amedea Pharma which is called Medical Affairs Innovation Olympics #MAIO2022 and #MAIO2023. In this episode I share the opening presentation on September 18 from the latest 2023 event the slogan of which was "Reclaim Our Health, Revive Our Planet". In my remarks, I revisit the ultimate purpose and duty of healthcare professionals to enable the next generations to live longer and healthier lives as well as describe why the life science industry has to learn from the lessons from the Renaissance on leadership, equity, and social impact, ESG, DEI, among others. I share some of the latest research on polarization in healthcare, healthcare professional shortages, patient trust in physicians and the industry or the media, shifting landscape of clinical decision-making with a focus on the three themes of this year's event - advancing access, continuity, and quality of healthcare. 0:00 Episode Introduction and Olympic Theme Music 2:29 Medical Affairs Innovation Olympics #MAIO2023 Opening Ceremony - Dedication to the Next Generation 3:15 Longevity of the Children of our next Generations 4:47 Critical Dichotomy of Unprecedented Innovation in Healthcare vs Global Economic & Political Conflict 5:05 MELLODDY: Machine Learning Ledger Orchestration for Drug Discovery to shorted time for drug development 5:50 "We no longer live in the era of war" argument for peace 6:10 Why we are all in need of a new renaissance in healthcare: economic fears, polarization and its drivers, decreasing patient trust in physician authority, media or industry, healthcare professional shortage crisis 7:13 Growing challenge among patients in taking care of their health despite unlimited sources of medical information 7:43 Patient health extends beyond physical well-being to quality and sustainability of life 8:52 Breaking down the Renaissance to integrate it into Medicine 10:40 Summary of the Lessons from the Renaissance - 1)innovating by revisiting lessons from antique history, 2) integrating expertise across finance, banking, art, and science; 3) closing the leadership gap between generations; 4) make innovation accessing to the public - health equity 11:08 The Renaissance drivers of today: ESG, Corporate Social Responsibility, DEI 11:48 Access, Continuity, and Quality of Healthcare - Top 3 priorities and themes for the 2023 Innovation Olympics 13:10 The New Innovation Spectrum: from Inspiration to Incentive to Investment 14:24 Critical Need to link Medical contributions directly to Economic Prosperity and Healthcare Community of our planet I hope you find this glimpse into our Olympic village inspiring - look for more episodes from the Innovation Olympics series from some unforgettable Olympic champions and healthcare leaders in the future episodes!

82 episod

#Business #Alloutcoach Tim

NEW RENAISSANCE IN HEALTHCARE - INNOVATION OLYMPICS SERIES EPISODE 1

Alloutcoach

published about a year ago

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MP3•Laman utama episod

82 episod

#Business #Alloutcoach Tim

Semua episod

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TOP FIVE LESSONS FROM THE 2024 PARIS OLYMPICS 37:03

11 weeks ago37:03

37:03

This last Alloutcoach podcast episode of 2024 is the most personal and revealing to date. I openly reflect on my own performance and journey through successes and failures in my career in pharma and biotech. The discussion directly addresses the most critical external and internal factors that are driving the new reality of competition in healthcare and life sciences, pointing out key differences in our perceptions of external/internal competition in the world of sports versus pharma. Finally, the episode is centered on the most memorable examples of athletes or teams and their performances or disappointments at the 2024 Paris Olympics to provide 5 critical business lessons for individuals or organizations in the healthcare industry and beyond for a stronger, transformative 2025 year ahead. 0:00 Episode Intro Music 0:07 Highlight #1 – Three Times I was fired / laid off 2:45 Highlight #2 – Noah Lyles’ loss of gold medal at his best event – 200-meter sprint 3:35 Highilght #3 – Recipe for Consistency of High Performance 6:13 Episode Introduction – Summary of the 2024 Medical Affairs Innovation Olympics Opening Remarks 7:52 Detailed Episode Outline 8:49 Current State of Competition in Medical Affairs and Healthcare Industry External and Internal Pressures of Competition and their Consequences. Major Layoffs due to changing workflows and inaccurate forecasting. Need of Medical Affairs to discover new power in medical decisions to stay competitive. 2024 Medical Affairs Innovation Spectrum – collaborating with tech to describe, predict, and prescribe best personalized treatments. 12:20 Our Perceptions of Competition vs Reality in Sports vs Pharma / Biotech Life Compass with only two directions – Progress and Success 14:03 Why I have always gone to work as if it were a sport I liked to master 15:07 Case Study – Leading Medical to grow a Pharma Startup by $40 million through a head-to-head study analysis 18:07 Personal Reflection and Analysis – Why I was fired / reorganized / laid off three times 23:14 Paris 2024 Olympics Lesson #1 – Respect Your Competition Noah Lyles’ claims of superiority in an event he dominated and disappointing bronze medal. Recent personal observation and outcome of a child celebrating another’s failure and waiting for him to fail. Gary Hall Jr, 5-time Olympic Gold Medalist – won his first Olympic gold only after he began to respect his arch rival. 27:58 Paris 2024 Olympics Lesson #2 – It is the Final Lean that Counts Noah Lyles’ closest margin of gold medal victory in the 100-meter sprint. Dominant Italian national teams in volleyball and water polo at the opening group stage missed the podium and could not medal. 29:51 Paris 2024 Olympics Lesson #3 - Recipe of Consistency is Proportions not Ingredients Alone Carl Lewis’ remarkable consistency of winning 4 consecutive Olympic gold medals in the long jump. Greek Long Jumper Miltiadis Tentoglou and Women’s South Korean Archery Team’s Consistency of defending their gold medals at the Paris Olympics. Personal application of mastering cooking pasta professionally to mixing highest quality talent on a team with the right proportion and size of equipment and environment. 33:20 Paris 2024 Olympics Lesson #4 – Never Bypass the Basics to Stay in Competition US Men’s 4 x 100 Sprint Relay Team’s Inefficient Baton Pass Marquis Dendy, US veteran, best current long jumper’s Damian Warner, Canadian decathlete Olympic gold medalist’s failure to post a jump at the opening height in the pole vault to miss the podium. 35:13 Paris 2024 Olympics Lesson #5 – Adapt to New Rules and Formats The judge or new competition format led to an unpredictable result with a favorite team not able to adapt in Paris. Celebrate Competition in Medical Affairs to stay competitive and relevant…

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LIVE DEBATE - ARE RANDOMIZED CONTROLLED STUDIES THE GOLD STANDARD? 54:57

13 weeks ago54:57

54:57

Clinical research is undergoing a revolution in light of new demands for speed and opportunities from a technological standpoint. These trends have given rise to a debate about the quality and clinical meaning of traditional methods of investigations versus modern types of clinical studies to collect real world evidence. This debate at the 3rd annual Medical Affairs Innovation Olympics #MAIO2024 in a unique and exciting format with a live poll at the conclusion, features an animated discussion from three speakers: Rashad Massoud, MD, MPH, CEO of Rashad Massoud Associates, LLC., globally recognized healthcare quality expert, physician, formerly visiting faculty at the T.H. Chan School of Public Health; Suzanne Pavon (moderator), Doctor of Pharmacy, Board Member at Iethico, former Vice President of Pharmacovigilance and Quality at Argenx; and Sana Syed, Senior Medical Director - Clinical Lead at Sanofi and public health expert formerly at T.H. Chang School of Public Health. Debate Objectives: ● To discuss the utility of RCTs in research and learning ● To discuss the challenges in translating RCT findings into the real-world environment ● To review the utility of the RCT approach to facilitate real world implementation ● To review the impact of the RCT approach for impact and limitations ● To discuss alternative research methods for research and learning ● To conclude with the research approaches that fit best for clinical trials and the real world; indicating a need for an adaptive, dual approach. 0:00 Alloutcoach Intro Music 0:09 Episode Highlight 3:09 Innovation Olympics Introduction 4:44 Debate Rules & Introduction 6:30 RCTs are the Gold Standard for Research and Learning - For the Motion - Sana Syed 8:12 The Scientific Method - Standard RCT Design 9:46 Rare Disease Case Study 11:38 Translating Biology vs Translating Real World Factors 14:34 Diversity of patients critical for data to represent populations 18:50 RCTs are NOT the Gold Standard for Research: Against the Motion - Rashad Massoud 20:27 Properties of an RCT 21:19 Other Research Questions to Eliminate Other Factors that may influence the results 24:13 Access Questions and Outcomes of Interest - Discovery and Delivery 24:48 Agency for Healthcare Research and Quality (AHRQ) - ~17 yrs to translate data into real world 26:33 Efficacy vs. Effectiveness Research 31:02 Concluding Remarks - case study in which RCT designs are not beneficial 35:30 Question: Health Avatar and AI to create real and virtual control arm Using virtual control arm using real world databases using Bayesian statistical methods 39:23 Case study to emphasize Harnessing Tacit knowledge 42:02 Comment: Weaknesses in generating data we can translate into populations 43:44 Question: Are we creating RCTs from virtual patients or classical RCT design? 47:34 Final Comments - For the Motion, Sana Syed Clinical Studies and Scientific Method - adjustments in diverse patient recruitment tactics 49:31 Final Comments - Against the Motion, Rashad Massoud 53:14 Live Voting Results…

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LONGEVITY & PREVENTIVE MEDICINE: UPDATE OF THE LANDSCAPE 24:42

15 weeks ago24:42

24:42

In this special episode you will have an opportunity to learn about the key factors to not only living longer but better and higher quality lives from a global expert and pioneer researcher in longevity medicine, Dr. David Barzilai. David provided an update of the landscape in this field as a keynote speaker at the 3rd annual Medical Affairs Innovation Olympics held in October. David is CEO and founder of Healthspan Coaching, LLC., and agingdoc.com, providing longevity medicine and lifestyle consulting. Dr. Barzilai is a Diplomate at the American Board of Lifestyle. He is board-certified in dermatology, with a PhD focused on evidence-based medicine, and also holds an MBA. In his keynote presentation, Dr. Barzilai critically addresses the gaps in treating only one disease at a time and provides alternative methods that target root, underlying causes of disease that can prevent multiple chronic diseases and lengthen the human Healthspan. David challenges the healthcare community and Medical Affairs function in pharma and biotech with a call to action to prioritize efforts to improve healthspan and transform medicine. 0:00 Timeline 0:09 Episode Highlight + Call to Action 1:30 Host Introduction of the Episode 4:17 Keynote Speaker's Presentation Overview 5:04 Dramatic Increase in Global Aging Population 6:10 Gray Tsunami Economic Impact - Rising Health Expenditures 7:07 Healthspan must accompany lifespan increase - Holy Grail of Longevity 7:41 Targeting the Bioscience of Aging: The Geroscience Hypothesis 8:21 12 Hallmarks of Aging 9:29 Problem with Current Approach of Targeting 1 Disease at a Time 10:26 Aging can be manipulated across different species Rapamycin increased lifespan even after being injected in middle aged humans 12:22 Growing Frontier in Longevity Biotech Number of biotech companies have grown from 20 to 50 since 2020 13:57 Lifestyle Medicine as Longevity Foundation 15:12 Global Strategy for Healthy Longevity Global Roadmap to Healthy Longevity National Academy of Medicine - Goal to Increase Lifespan by 6 years by 2030 15:47 Hevolution Foundation - $1 billion investment to accelerate in aging research 16:31 Bridging the gap between biotech and public health initiatives Immediate reforms in healthcare are needed such as compression of morbidity 17:13 Tackle Urgent Challenges of Aging where health is not just preserved but extended Call to Action Integrate Biotech and Public Health Strategies Invest in Aging BIology Train Physician Workforce Promise of Geroscience 19:09 Q & A 20:10 Questions: Roles of 1) Neuralink + 2) Telehealth on Longevity 21:07 Role of Telehealth - know your target audience/sub-specialization is a key factor 22:24 Neuralink comments - exponential increase of dementia…

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FINDING THE RHYTHM OF RECORD-BREAKING JUMPS IN SPORTS, CAREER, AND LIFE 48:25

17 weeks ago48:25

48:25

Bob Beamon is a multi-talented champion that has followed the path of his own inspiration to generate excitement and purpose throughout life. In order to succeed and leave a legacy on others, he had to make the decisive steps to make the right jumps in sports to break longest-standing world and Olympic records as well as in life to follow his many dreams and succeed. At the 3rd annual Medical Affairs Innovation Olympics, I sat down with Bob Beamon to learn how his sports career and multiple inspirations (basketball) influenced the decisions he has made in his personal life and success in continuing to reinvent himself as a champion in music. We explored explore what makes the long jump one of the most classic and difficult events in track and field and possibly sports, the individual components and mechanics of the jump, how his talent, circumstances, and training led to his success. In addition, he discusses his personal theories on competition, approaches to edging out competitors in sports, and transition into how he defines competition in life and what impact his environment, character, and personal inspiration have played on the kinds of jumps he has had to make in his personal life to follow multiple different and challenging paths yet succeed. In this absolutely inspirational and candid discussion, Bob speaks about his own health, how healthcare professionals throughout his career and life have helped him make personal decisions, the role his coaches and training have had on his health after retiring from sports, and what types of innovation inspire him currently or those he hopes to see in healthcare in particular. 0:00 Episode Intro 2:17 Keynote Speaker Welcome 4:20 First Jump in Bob's Life that shaped his career afterwards. Bob's tough childhood and background 8:42 Basketball and Track Field in Police Athletic League Activities Bob wanted to find a sport in which he could simply win. 10:07 First long jump at age of 10 was 19 feet 10:43 Bob's personal approach and philosophy on competition His motivation was to be "somebody special" and "proving to people" he was going to be a "shining star" in his community. 12:23 Daily discipline of practice His goal was not only Athletic but Personal and Social Achievement 13:04 First time he competed in the Junior Olympics 14:29 Bob had no coach or supporter at the Junior Olympics He jumped 24 feet 1 inch and newspapers mentioned him as a "future Olympian" 15:18 Dean of Students became Bob's coach and "saving graces" Larry Ellis 16:47 What part of his success was due to his God-given talent vs training? Bob had the foundation - basics of jumping. He was always open to Learning and to making himself feel good about what he was doing. His drive was rooted deep inside. 19:19 How Bob put the world-record performance together in Mexico City He trained with the fastest sprinters in the world which 21:07 What makes the long jump one of the most difficult disciplines? His strong inner spirit helped him. He knew deep inside he would one day be successful. He had lost so often that he felt even 23:23 How becoming a champion influenced Bob's career and life? Many athletes are lost and do not know how to transition after ending their sports career. We need to coach athletes and prepare them for life after sports. 26:53 Bob's problem with blood pressure and kidneys 29:10 Message on healthcare innovation to the medical community Bob educated people on hypertension through opportunities opened by pharma companies. He developed kidney problems and diabetes. He dealt with health problems like a sports athlete, like an intelligent athlete. I am going to continue to be a winner. 33:33 How Bob has reinvented himself recently as a musician, drummer 38:25 Bob's experience as a percussionist and favorite instruments 42:20 How do you teach someone to find the fire inside them" Open up - How you really feel about yourself helps you open yourself to win, achieve, and find opportunities.…

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OLYMPIC GOLD MEDALIST LEGEND BOB BEAMON'S STORY BEHIND HIS RECORD JUMPS IN LIFE AND SPORTS 47:25

17 weeks ago47:25

47:25

Bob Beamon is a multi-talented Olympic champion that has followed the "beat" of his own inspiration to make the right jumps in sports and throughout his life. In order to succeed and leave a legacy on others, he had to make the decisive steps in sports to break the longest-standing world and Olympic records as well as in life to follow and achieve his many dreams. On this episode of the @Alloutcoach podcast where sportsmanship meets the scientific method, I sat down with Bob Beamon to learn how his sports career and multiple inspirations (basketball) influenced the decisions he has made in his personal life and success in continuing to reinvent himself as a champion in music. In this conversation leading to his keynote presentation at the 3rd annual Medical Affairs Innovation Olympics event (see follow up episode - stay tuned), Bob presents a very personal, detailed account of how his particular talent, challenging circumstances, approaches to training as well as facing adversity led to his success. In addition, he demonstrates the role his life inspiration and sports competitor's character played on reinventing himself throughout his career across his life transitions including the latest one in retirement as a musician. 0:00 Episode Highlight 1:04 Episode Intro 3:08 What inspired Bob to become a sports athlete Growing up in South Jamaica, New York, rough childhood. Bob's involvement in the Police Athletic League thanks to which he started to compete in track and field. 6:04 Bob did not stop competing because he lost consistently 8:02 Transition from sprint to long jump 8:46 First long jump competition - 19 feet at 10 years of age 10:32 Bob's family background and early loss of his mother 12:38 Junior Olympics in New York - Turning Point at age 14 15:09 What makes the long jump special and difficult Bob's background in the triple jump. He had jumped 25 feet 6 inches in high school. The event requires consistency in training, coaching, and inner drive. 20:48 Bob's coach Larry Ellis did not force Bob to change his peculiar form of jumping Bob's technique - jump over a hurdle during training to maintain a height. He perfected an "unorthodox" form of jumping. 24:43 Reliving Bob's 1968 World Record Jump in Mexico City 26:38 Advantage of working out with best sprinters in the world Bob's adjustments to the long jump the day before the final only qualifying on the last attempt. 30:12 Bob's Attitude & Mindset on the morning of his World Record 32:16 Specific Goal of Winning Olympic Gold vs. World Record 34:26 The emotions of breaking a world record 38:46 Nothing compares to the Intensity of the Olympics 41:02 How Bob reinvented himself as a musician at age 77 43:48 Welcoming the new challenge of becoming a drummer Bob played with a Grammy-award winning band, opened the Track and Field competition at the Paris 2024 Olympics with a musical performance…

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SPRINT & LONG JUMP TO LEAVE A NEW MARK ON HEALTHCARE QUALITY 57:43

33 weeks ago57:43

57:43

This is a special Episode Edition on the @Alloutcoach Podcast. Tune into this memorable highlight from the 2023 Medical Affairs Innovation Olympics event Opening Ceremony full of real-world practical case studies, striking new statistics, and critical commentary - an expert panel discussion about the details necessary to make both short-term and long-term marks on improving healthcare quality from both the perspective of a globally recognized healthcare quality expert physician and public health speaker, Dr. Rashad Massoud (Visiting Faculty T.H. Chan School of Public Health), and of an innovative pharma industry executive recognized for his leadership and dedication to patient advocacy groups, holding senior leadership roles in Commercial, Marketing, Market Access and most recently in Medical Affairs, Rob Adamoski (Vice President, Corcept Therapeutics). 0:00 Intro Music 0:22 Episode Highlight Cushing Syndrome Case Study - Perception Gap on Treatment Quality between Patients vs their Healthcare Providers. 1:58 Speaker Introductions 4:11 Panel Discussion Outline 4:38 Global Healthcare Quality Improvement Case Study USAID Applying Chronic Care Model to Improve Coverage, Retention, and Clinical Outcomes: Uganda 16:46 Role Medical Affairs in Pharma can Play on Health Quality 17:56 Connection to Disease - Stimulating Purpose in Medical Affairs 19:29 Value of Recent and Relevant Clinical Experience in Medical Affairs 20:21 Aiming for Diversity of Experience across entire Care Continuum 22:07 Finding the Right Balance on Your Medical Affairs Team 22:58 Case Study: Personalized Medical Liaison led Executive Staff training 25:01 Critical Gaps in Training in Medical Affairs Team - benchmarking data Larger Organizations offer more training opportunities vs mid-sized and smaller pharma or biotech companies in Medical Affairs. Only 42% of Medical Affairs organizations provide any training and only 23% of small pharma companies (Medical Affairs Professional Society) 27:01 Why Most of Us in Medical Affairs believe Metrics are not Meaningful 28:57 Power of a Graded Data Science based KPI Feedback Loop 30:12 2023 Medical Affairs Metrics Global Benchmarking Gap in Analysis70% of Medical Affairs companies do not systematically analyze how their activities lead to outcomes 30:41 The Motive to Measure Performance in Medical Affairs with KPIs 31:24 Medical Productivity Index (MPI) Model to Increase Performance 32:25 Integrating Health Systems Approaches to Metrics in PharmaAll-Mobile Hypertension Clinics that improved quality and bridges health equity gaps - India Case Study 42:38 Medical Affairs Improving Healthcare Decisions - Patient Advocacy 47:00 How Healthcare Cost relates to Quality - latest trends 49:44 How can we make Healthcare Jobs Desirable again? 52:40 Improving Quality w/ 1) Accountability & 2) Transparent Data Culture…

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THE MENTORSHIP WAY TO CAREER MIRACLES & BUSINESS PROFITS 32:39

35 weeks ago32:39

32:39

This latest episode is centered around discussing how mentorship directly impacts our bottom line in business and personal career based on real-world examples and decades of research. I speak about this topic with a returning guest on the show, co-author of a new book and practical step by step guide just published called "Financial Times Guide to Mentoring" , Dr. Ruth Gotian, Chief Learning Officer at Weill Cornell Medicine in New York. Dr. Gotian is a globally recognized mentorship expert by Nature, Wall Street Journal and Columbia University who named her a top 20 mentor worldwide, a mentorship thought leader ranked by Thinkers50 as the #1 emerging management thinker in the world in 2021, award-winning book author of "The Success Factor" previously featured on Alloutcoach, and prolific contributor to Harvard Business Review, Forbes, and Psychology Today having interviewed Nobel Prize winners, astronauts, Olympic champions, leading physicians and scientists of our time, among others. 0:00 Episode Highlight 0:44 Episode and Guest Introduction 3:08 Advantages and disadvantages of formal versus informal mentorship programs 61% of mentorship is informal. Formal mentorship programs can however be a launching pad for those uncomfortable to seek out mentors or mentees 5:23 Why is it crucial to find mentors outside of your direct line of management? It is important to diversify mentors in case they leave or you decide to leave. 7:14 Shared experiences in mentorship and how to identify informal mentors Steve Kerr, NBA champion and coach's example of his lesson from a football coach and mentor: Mentorship is more than technical coaching or shared experiences. It is about shared values and the kind of culture you create in a relationship. 9:13 How mentors make impact business bottom line and job satisfaction Those who have a mentor earn more, are happier at work, and stay longer. 89% of employees with mentors feel their contributions are valued by others. 11:28 Most common barriers and misconceptions in mentorship 15:36 How do you continue to learn informally despite higher titles or roles? 18:29 What proportion of mentorship should be informal vs. formal or experiential? 22:40 Should minorities, women, etc seek mentors with the same background? 24:41 What surprised Dr. Gotian during the writing process of her latest book? 25:45 How Dr. Gotian and her co-author Andy Lopata complement each other? 27:52 How do you tell when mentorship is successful? 29:38 Biggest achievement with "Financial Times Guide to Mentoring" 31:11 How Dr. Gotian is stretching herself and lifting others in her next projects…

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COMBINING MOTIVATION & PROBLEM SOLVING TO GROW BUSINESS PERFORMANCE 46:27

35 weeks ago46:27

46:27

On the latest episode of Alloutcoach, I spoke to Neel Doshi whose research on human motivation and performance has inspired me over the years. Watch this video podcast to understand why I consider him one of the brightest minds in organizational change research who has created forward-thinking solutions that can transform your business. Neel Doshi is Co-founder and CEO of Vega Factor and Factor.AI https://www.factor.ai, NY Times and Wall Street Journal best-selling author of "Primed to Perform", multiple award-winning founder of various tech startups, MIT graduate in engineering and Wharton Business School MBA. 0:00 Intro 0:08 Episode Highlight 1:52 Neel Doshi Introduction 3:30 Why Neel decided to study human performance at work His journey from first job as software engineer at major bank and personal frustration from lack fulfillment and mediocre attempt at starting a company to researching the root causes and drivers of human motivation at work for the next 15 years 7:56 Various types of industries Neel Doshi has researched 8:58 Distinguishing and Ranking Tactical vs. Adaptive Types of Performance at work Tactical Performance refers to alignment to roles, objectives, and goals while adaptive performance refers to innovation, problem-solving, and improvisation. 13:23 Measuring Motivation to produce both Tactical and Adaptive Performance at Factor.AI Research indicates 6 motivational factors along a spectrum of stimulating or inhibiting performance: 1) play 2) purpose 3) potential (3 positive factors that stimulate adaptive performance), followed by 4) emotional pressure, 5) economic pressure, and 6) inertia (3 negative / inhibiting factors) in descending order 21:42 Tesla Model 3 Mass Market Case Study Real-world example confirming that relying completely on Tactical Performance alone through technology is insufficient and detrimental, and Adaptive Performance via human capacity to think critically is central to driving growth in business. Elon Musk's 2009 Tweet: "Excessive automation at Tesla was a mistake. To be precise, my mistake. Humans are underrated". 24:50 How do you measure performance through profitability vs social impact? Majority of the motivation of performance is local to the employee not global to the company. This is why social impact is not a driver of motivation or performance. 29:20 How to both perform and collaborate today when the pace of competition is rising so rapidly. Companies do not have to turn increasing external competition and global pressures into coersion and blame. They can make competition fun. Competition can make work more purposeful because an employee can feel like he/she matters more in the presence of an adversary. Companies turn competition into pressure rather than play and purpose. Play and purpose, our highest performance motivators are not bound by a limit and do not represent a zero-sum game unlike emotional or economic pressure, for example. So if companies are using emotional or economic pressure or indirect motives to drive performance they are fracturing collaboration by design. Collaboration suffers, and so does problem-solving and adaptive performance. When I do not have companies I work with that have internal competition, I create competitions. 35:13 What are some examples of new ways of working to drive higher motivation at work? Hierarchies and distinct roles are important to communicate diverse vantage points and perspectives. Metrics make work more fun because they provide a scoreboard to a game and can drive stronger performance as long as they are not weaponized by leaders. Similarly, performance reviews should be used not to blame and shame people but should involve teams to evaluate team performance together rather than use individual reviews to measure teams. 45:10 How Neel is currently stretching himself and lifting others Engineering stronger performance has become a science and there are specific solutions we have now built that are available for you.…

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PERSONALIZED MEDICINE WITH PHAGE THERAPY TO TARGET PATIENTS AND BACTERIA 27:25

38 weeks ago27:25

27:25

In this Part 2 of the Alloutcoach podcast episode focused on phage therapy to fight infections and antimicrobial resistance, I spoke to the Chief Physician at the globally leading center of excellence of an alternative, effective treatment approach to antibiotics, Dr. Dea Nizharadze at the Eliava Phage Therapy Center (EPTC) based in Tbilisi, Georgia. She explains the basic principles of phage treatments, its unique qualities, advantages and real-world clinical examples of methods and types of patients and infections this personalized therapy specifically targets. 0:00 Episode Introduction 1:42 Why the Republic of Georgia is a global leader in phage therapy 2:39 How phage therapy works in bacterial infections?Eliava Phage Therapy Center (EPTC) was founded in 1923 by Professor George Eliava who had collaborated with Felix D'Herelle, who had discovered phages, and while most other countries turned to antibiotics only, it is the only institution in the world that has continued to research bacteriophages without a pause of even one day since its inception and therefore collected the greatest research and real-world clinical experience with phages. 5:34 How do phages work to eradicate or stop further growth of bacteria? Phages are biological "weapons" against bacteria, namely viruses that target specific microbes only, without destroying the "good" bacteria or microbiota. They are naturally occurring substances and have no safety concerns. In some patients with antimicrobial resistance phage therapy enables improvement in sensitivity. 10:42 Synergistic effect of phage combination therapy with antibiotics 11:58 Phage Therapy Doisng and Success Factors 15:14 Length of phage treatmentIn chronic infections phage therapy may divided into 3 stages and last 15-20 days, and varies by nature and severity of disease. Patient treatment includes days off therapy, or holidays, however, bacterial analysis is continued and patient condition is monitored throughout the entire course of treatment. Success of therapy is indicated when bacterial titers and virulence decrease or bacteria are eradicated. Patient's objective and subjective signs and symptoms often vary throughout response to therapy. 16:42 Phage Product Variability and Market Availability How do we ensure educating patients to access the correct, most appropriate therapy for their infections 17:35 Multi-disciplinary personalized team care and telemedicine 19:53 Steps for patients outside of Georgia to access phage therapy via telemedicine? 24:04 Affordability and access to phage treatments 25:23 How to contact Eliava Phage Therapy Center…

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REVIVING PHAGE DISCOVERY TO FIGHT INFECTIONS AND ANTIMICROBIAL RESISTANCE 19:19

39 weeks ago19:19

19:19

In this special episode I spoke with an international guest from my native country, Republic of Georgia, and global ambassador of a critical alternative solution against tough chronic infections and antimicrobial resistance on behalf of a global center of excellence in bacteriophage therapy, discovered over 100 years ago. My guest, Davit Sturua, Doctor of Business Administration, Public Health and Medical Tourism expert, is the director of the Eliava Phage Therapy Center, a global leader in real-world, clinical, research, and commercial experience with naturally occurring bacteriophage treatments. He discusses the Georgian center's 100-year old history and evolution, its extensive experience treating patients across 84 countries, explains the current global public health problem, and provides an update along with rationale on the recent growth in clinical studies investigating phage therapy across the globe in this part 1 of 2 episodes on this topic. Watch this episode with English subtitles to learn about how you, your friends, family, healthcare payers and experts, healthcare providers, patients and their loved ones can consider alternative options via telemedicine or in person to treat chronic, tough bacterial infections or prevent antimicrobial resistance. Stay tuned for the next episode (part 2) on this topic with my guest Dr. Dea Nizharadze, Chief Physician at the Eliava Phage Therapy Center, who delves deeper into the typical course of treatment, patient journey, and various scientific attributes of phage treatments. 0:00 Introduction 0:08 Introduction in English 2:19 Special Guest Mr. Davit Sturua, Director of Eliava Phage Therapy Center Introduction in English 4:34 Episode Introduction in Georgian (English subtitles) 4:53 Overview of Part 1: Overview of 100-year history of Eliava Phage Therapy Center, its advances, growth, current goals and Part 2: Scientific Rationale for phage treatment, appropriate patients, typical course of treatment, and access to care for patients worldwide 5:54 Davit's personal inspiration and history at the Eliava Center 10:27 How is EPTC raising awareness about phage therapy outside of Georgia? The center has treated patients from 84 different countries in 2023 alone. The majority of patients internationally who obtain care from EPTC suffer from various antibiotic-resistant or chronic infections. 12:20 5 million patients die from antimicrobial resistantce every year - underestimation, with tens of millions of deaths projected by 2050 13:04 Future Scientific and Commercial goals of Eliava Center to expand globally, standardize phage production to meet GMP standards, conduct randomized clinical studies and secure access for patients worldwide 15:23 Challenges in scaling phage production and quality standardization. Georgia is currently a global leader in commercial production of bacterial phage treatments. While only a few years ago there were only a handful of clinical studies conducted globally, currently there are over 50 clinical studies in 2023-2024 alone over the past year being conducted in the United States alone. Similarly, other European countries, particularly Great Britain are also actively pursuing and advancing clinical research in bacteriophage therapies. Government and research funding in phage treatment is therefore continuing to grow rapidly. 18:33 Final Greetings - Conclusion of Part 1. Invitation to partner across Europe and the U.S. with the Eliava Phage Therapy Center…

1
HEALTH EMERGENCY DESPITE ADVANCES IN TREATMENTS FOR OBESITY 42:14

44 weeks ago42:14

42:14

Patients with obesity are at the forefront of latest developments in medicine once again, with new options but many new questions still to be solved, including a public health emergency and shortage despite the latest advances. In this latest interview Angela Fitch MD, FACP, FOMA, Dipl. ABOM critically reviews the advances, public health emergency, and problems with patient access to obesity treatments with an important call to action to the entire healthcare community. She offers a scientific overview of latest obesity treatments, incredibly practical solutions as well as valuable tips for treatments of obesity you do not want to miss! Angela Fitch, MD, FACP, FOMA is a leader in the field of obesity medicine, immediate past president of the Obesity Medicine Association, Assistant Professor of Medicine at Harvard University, and former co-director of the Massachusetts General Hospital Weight Center. She is a dedicated clinician, as well as an activist for obesity medicine, board member of the Obesity Action Coalition, and a founding member of the Massachusetts Coalition for Action on Obesity. 0:00 Episode Highlights - Public Health Emergency: only 5-10% of 140 million patients w/ access to obesity care 1:36 Episode + Guest Introduction 3:31 Inspiration behind Dr. Angela Fitch's activism + specialization in Obesity 3:56 Background in engineering, primary care with GLP1 agonists 5:16 Obesity is a heterogeneous chronic disease 7:26 How far we have advanced in obesity treatments from phentermine and topiramate to semaglutide (Wegovy)or tirzepatide (Zepbound) and their relative probability in losing 20% bodyweight 8:49 Surgery vs newer GLP1 and other obesity treatments and new investigational drug retatrutide 10:03 Triple mechanism of experimental new obesity drug retatrutide 10:16 Comparison of Tirzpatide - double agonist (GLP1 / GIP): Semaglutide - single mechanism (GLP1) agonist, and retatrutide - triple agonist (GLP1, GIP, and glucagon) 11:18 Success Factors in Obesity Treatments 13:01 Why lifestyle and diet are not effective in many patients 13:41 Personal case study of diet and weight loss with associated GERD 14:24 Dr. Fitch's lifestyle tips: 5P's: planned portions, plants + protein, power, pillow, pause 15:48 Our society does not promote healthy nutrition 18:38 Lifestyle effective in only 5% of patients with obesity 19:02 Weight loss and maintenance - two different biologic phenomena 21:00 How to gain a Metabolic Advantage 23:28 Weight loss maintenance post surgery vs medications 25:32 How patients can access drugs despite obesity medicine shortage 26:06 Public Health Emergency - Obesity Medicine is not a Standard health insurance benefit in the U.S. 28:33 140 million Americans qualify for treatment, but only 5-10% receive it 29:26 Why we are awaiting new drug approvals - why patients are turning to non-FDA approved options 31:00 Reality - alternative ways patients are accessing obesity treatments 31:36 Dr. Fitch's solutions - declare public health emergency, consider vial formulations, coordinate comprehensive care 34:42 Call to Action and Challenge to Healthcare Community 39:23 Dr. Fitch's Current and Future Focus 39:57 Expansion of Dr. Fitch's knownwell patient centered medical home & collaborative practice across new locations in the U.S., 75% telemedicine…

1
RESOLVING ROOT CAUSES OF CHRONIC DISEASE WITH DIGITAL INNOVATION 31:13

48 weeks ago31:13

31:13

If you have an interest in digital health or digital therapeutics and want to know the latest analyses, trends, and tangible lessons, my latest guest on Alloutcoach, Giorgia Pezzotta is the person I strongly recommend that you follow. Giorgia is a health and innovation engineer, emerging leader, and entrepreneur recognized among 100 under 35 young talents by Financial Times to innovate the "future of Italian entrepreneurship worldwide". She is personally committed to driving change, creating strategic innovation, and promoting social impact. Her purpose is to ensure that innovation and technology improve people's health and healthcare management, and deliver a better future for our society. She works as Key Account Project Manager at a French unicorn digital health company Doctolib, and an instrumental part of the Italian launch team of hospitals. Doctolib is the first digital health service in Europe and one of the fastest-growing healthcare tech companies. Giorgia previously served as a healthcare consultant at KPMG Advisory S.p.A. 0:00 Highlight from Episode - Advantages of continuous monitoring of root causes of chronic disease with remote patient monitoring, digital wearables and telemedicine to reach more patients in rural areas 1:45 Episode + Guest Introduction 3:44 Giorgia's Journey to her Passion for Health Innovation 7:58 Unique Learning Motive behind Digital Health Content Strategy 8:48 What are the latest health innovations with biggest impact on patients? 13:57 Where are the biggest investments focused on health innovation? 16:14 What are some quality metrics and standards among different Digital Health products? 19:08 Are there any plans to accelerate regulation and approval of digital therapeutics globally? 22:11 How should patients choose which digital health app to use? 25:36 Lessons for Entrepreneurs in Digital Health 28:47 Final Message: Importance of finding someone who believes in you…

1
WHY GOING TO WORK SHOULD BE LIKE COMPETING IN A SPORT 54:03

50 weeks ago54:03

54:03

In this new "InWeekend" series premiere of the podcast, the host, Tim Mikhelashvili, CEO of Amedea Pharma shares real world lessons from his career in the Medical Affairs function in the pharmaceutical industry to propose a modern approach to raising new standards in healthcare quality and ways of working in an environment constrained by resources and increasingly exposed to data. He reviews 1 validated organizational change framework, 1 global case study, 5 latest research studies and benchmarking reports in the field or across different industries, cites clips from an organizational change expert Ron Carucci and a double Olympian swimmer Chris Cook to debate why work should be like a sport for a diverse, multi-functional profession not directly tied to revenue, to consistently improve its Medical Impact on patient outcomes and business profit. 0:09 Intro 0:47 "InWeekend" Series Premiere Description 1:14 Episode Intro 2:18 Change Perspective from Performance Review to Personal Record 3:15 Article Overview - Approach to New Ways of Working 3:40 Lessons from Career 4:25 What "Going to Work as if Competing in a Sport" means for Medical Affairs / Healthcare 4:56 Merging principles of Sportsmanship with Science at Amedea Pharma 5:04 Selecting the Right Data from Limitless Options to Show Medical Impact 6:31 Breaking Down Performance into Activities and Outcomes to make Metrics Meaningful 7:30 Metrics and Human Ambition addressing the Competitors in All of Us 8:27 Three outcomes of avoiding human ambition as leaders 11:19 Implicit vs Explicit Competition in a real-world case study 13:36 Origin of We vs They Internal Rivalries 15:22 Case Studies of Medical Affairs directly generating revenue 17:05 Cost of Decreased Cross-Functional Collaboration - Clip from Podcast with Ron Carucci 20:06 Healthcare as Cost vs Investment 22:21 Why Sports adds Certainty and Objectivity to Healthcare 23:17 Lack of personal recognition in Medical Affairs 24:11 Sports - Celebration of Personal Accountability 24:30 Why work is more like war today than sports 25:34 Addressing skeptics - why introduce more pressure through sports at work? 26:58 How true sports view of work sparks life in least competitive employees 27:41 Medical Affairs Innovation Olympics case study 29:19 ToMo - Total Motivational Factor Score Model overview 32:32 - Common Organizational Processes that improve employee motivation / engagement 34:27 Performance Evaluations Irrelevant to Job Role - recent research 35:15 Latest Medical Affairs Metrics Benchmarking Results and Gaps in meaning and analysis 39:50 Our Approach to Performance reflects how we view our responsibility 40:01 Recent study on lost productivity and money on subjective performance management 40:17 Recent HBR research on comparing employees against themselves versus against each other 41:57 Three questions to consider to improve performance metrics 43:04 Argument - what if we change/raise standards of performance management? 44:02 Chris Cook - Double Olympian swimmer's advice in a short podcast clip: Compete more often against yourself and against more people 48:54 The Competition Paradox: Lesson 49:33 Three Myths vs Facts on Performance Metrics 50:56 Final Advice to Stretch Yourself in Life 51:57 Personal Invitation to Sign Up for the 2024 Medical Affairs Innovation Olympic Trials…

1
DESIGNING THE HEALTHCARE DELIVERY OF OUR DREAMS WITH AI / ML TODAY 39:24

1 year ago39:24

39:24

On this special Live broadcast of the @Alloutcoach Podcast I welcomed back Dr. Pierantonio Russo, Chief Medical Officer at EVERSANA, cardiac and heart transplant surgeon trained at Mayo Clinic, academic medical school lecturer, expert in health economics and population medicine, bioinformatics, Machine Learning, and digital medicine to the show to share the highlights from his recent state of the art presentation of the "Hospital of the Future" in Rome, Italy. He is a renowned physician executive and speaker who has a healthcare experience from all its angles as a chief clinician in cardiac surgery, health insurance decision-maker, health system leader and administrator, and therefore shares his specific cases of med tech innovations already underway as well as the critical success factors including personalizing healthcare delivery using remote patient monitoring or applying social determinants of health data. 0:00 Episode Introduction 1:48 Dr. Pierantonio Russo - Journey of a Healthcare Career from all of its Angles 6:14 Health Innovations Already Underway w/ Strongest Impact 13:44 Why Certain Health Systems are More Successful in Adopting Innovation 15:28 When will Health Tech Innovations Go Mainstream to the Community 17:36 Specific Outcomes of AI / ML on Patient Outcomes 22:45 Role of Convenience in Health Innovation - Quadruple Aim 26:57 Impact of Med Tech on the Art of Medicine or Decision-Making 29:39 What are the economic real-world benefits of Med Tech? 32:18 AI/ML can improve Social Determinants of Care and Value-Based Care 35:17 Final Message: Critical Steps to Consider Which Technology to Implement in Medicine…

1
INNOVATIONS IN TEACHING MEDICINE AND TESTING VIA PODCASTS 25:57

1 year ago25:57

25:57

With rising socio-economic pressures on health systems and healthcare professionals to continue to deliver the best clinical outcomes, staff shortages and countless sources of Medical Information to support their approaches to patient care, the topic of practical methods of applying Medical Education in innovative ways has never been more critical. In this episode I speak to a renowned leader and expert in the industry of Medical Education, Rob Braun, President, Global Learning Collaborative - Omnia Education, Prova Education, Medtelligence, and AGILE with decades of experience in senior executive roles managing or advertising accredited Continuing Medical Education (CME) in oncology, women's health / gynecology, cardiology, neurology, dermatology, gastroenterology across pharma, biotech, and life sciences with recognized brands such as WebMD, and Mesdcape, among others. He shares his modern view of Medical Education focused podcasts and their ultimate practical value on improving patient outcomes by illustrating latest trends as well as insights from recent data. 0:00 Introduction 0:08 Speaker Introduction: Rob Braun 1:26 Rob's Intro: Global Learning Initiative 2:19 How does a podcast differentiate itself across different channels in impact on healthcare outcomes? 4:28 How does your approach help people apply the information rather than just listen? 8:13 How can we improve the impact of KPIs on patient outcomes in Medical Education and what roles can podcasts address these gaps? 10:32 What are some trends among the types of HCPs most likely to attend Med Ed podcasts? 12:56 Dr Ian Lang quote from 1991 13:23 How do you measure impact on clinical outcomes? 15:08 Is there a particular time range after the activity during which it is best to test knowledge? 16:30 What are some incentives you use for more HCPs to respond to Med Ed program outcomes surveys? 17:09 How has the quality of Med Ed programs changed in the recent years and what impact do the HCPs preferences have on these trends? 20:27 What makes continuing medical education that is accredited critically different from all other growing sources? 22:28 Where can HCPs, others tune in to participate in innovative Med Ed programs? 24:49 Final Message from Rob Braun: Creativity in Medical Education…

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NEW RENAISSANCE IN HEALTHCARE - INNOVATION OLYMPICS SERIES EPISODE 1