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ASME's Unconventional Engineering

ASME's Unconventional Engineering

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ASME's Executive Director/CEO Tom Costabile welcomes guests from across the world of mechanical engineering to discover the interesting and unconventional ways they are using their skills to advance engineering for the benefit of humanity.
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Driving the Discussion in Fatty Liver Disease. Join hepatology researcher and Key Opinion Leader Jörn Schattenberg, Liver Wellness Advocate Louise Campbell, and Forecasting and Pricing Guru Roger Green and a global group of Key Opinion Leaders and patient advocates as they discuss key issues in Fatty Liver disease, including epidemiology, drug development, clinical pathways, non-invasive testing, health economics and regulatory issues, from their own unique perspectives on the Surfing the MA ...
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Three Wisemen Podcast

Josh Vogt, Chris Blackwell, & Jeff King

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"Three Wisemen Still Figuring It Out" podcast is an insightful and refreshing show that explores the intricacies of life. Hosts Jeff King, Chris Blackwell, and Josh Vogt offer practical advice and valuable insights on topics ranging from personal growth and relationships to navigating modern society. With a focus on growth and self-improvement, the podcast provides a positive and uplifting listening experience. The hosts share their own relatable stories, successes, and failures to provide m ...
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Summary: In this episode, Gene discusses management principles and leadership strategies for senior leaders and aspiring entrepreneurs with Tom Heiser, previously CEO of ClickSoftware, EVP at EMC, and President at RSA the cyber division of EMC. They cover topics such as opening the aperture, balancing strategy and tactics, embracing change, connect…
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This week’s episode and the first episode of season 2 has Jordan Hartman telling us about the Avi Dog Program at Meadows and the film he helped make to give a behind the scenes look at it. Be sure to see the film at EVO Portland on Wednesday, September 25 at 6PM. More info, RSVP and vote at https://trewtoyouportland925.splashthat.com/?A360=31336095…
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Climate action is a long-term proposition that requires persistence and the ability to pivot where necessary. The ASME Committee on Sustainability, led by Chair Sean Bradshaw and Vice-Chair Timo Marquez, is charged with ensuring ASME remains committed to doing its part in contributing to the larger prospect of realizing actionable progress in addre…
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Jim Alkove, CEO and co-founder of Olaria, shares his career journey and insights on cybersecurity training and becoming a board advisor. He emphasizes the importance of starting at the beginning and gaining experience in software engineering during his time at Microsoft. Alkove highlights the need for a more diverse pool of candidates and situation…
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In this episode, Gene Fay interviews Ed Adams, President and CEO at Security Innovation, about his journey into cybersecurity and his work in advancing software security practices. Ed shares his story of transitioning from quality assurance in software at Rational Software to founding Security Innovation, a company focused on application security a…
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Two weeks ago, the SurfingMASH Question of the Week asked, "What structural or educational changes do you anticipate will significantly improve Provider-Patient communication? Will these changes require more from the provider and more from the patient?" Today, S5 E23 panelists Mike Betel and José Willemse join Roger Green to review the three answer…
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In the second half of Roger Green's interview with Global Liver Institute Vice President, Liver Programs Jeff McIntyre, Jeff discusses the implications of his key EASL Congress takeaways for GLI and other patient advocacy groups. To Jeff, this trend makes patient advocates a more valuable player in the clinical trial design process, particularly wh…
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This conversation contains the first half of Roger Green's interview with Global Liver Institute Vice President, Liver Programs Jeff McIntyre, during which the two discuss what Jeff considered the key strategic takeaways for GLI from the various EASL Congress presentations, abstracts and discussions. Jeff focuses on the "overriding sense of optimis…
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In the second half of Roger Green's interview with PharmaNest Founder and CEO Mathieu Petitjean, Matt discusses the implications of his key EASL Congress takeaways for PharmaNest. Matt starts this discussion with a simple question: Will biopsy-based analyses become part of a surrogate endpoint? As he points out, they are not today, and creating the…
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This conversation contains the first half of Roger Green's interview with PharmaNest Founder and CEO Mathieu Petitjean. After Matt tells the audience a little about his background and PhramaNest, the two discuss what Matt considered the key strategic takeaways for PharmaNest from the various EASL Congress presentations, abstracts and discussions. B…
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00:00:00 - Surf's Up: Season 5 Episode 24 This week's episode on MASLD lessons from the EASL Congress 2024 includes three separate elements: individual interviews with PharmaNext Founder and CEO Mathieu Petitjean and Global Liver Institute Vice President of Liver Programs Jeff McIntyre, followed by a discussion with patient advocates Mike Betel of …
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In this episode, Gene Fay interviews Sammy Migues, Principal at Imbricate Security, about his journey into cybersecurity and his work on the Building Security in Maturity Model (BSIMM). Sammy shares his experience starting in computer science in the late 1970s and how he became a computer security professional. He explains the motivation behind cre…
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This week, Surfing the MASH Tsunami looks back on interviews Roger Green conducted during the EASL Congress itself. This conversation with SurfingMASH co-host and Tawazun Health Founder and Clinical Director Louise Campbell took place on the last day of the Congress This portion of the conversation was not included in the original S5 E19 but instea…
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This week, Surfing the MASH Tsunami looks back on interviews Roger Green conducted during the EASL Congress itself. This conversation with Hepatology Key Opinion Leader and EASL Educational Councillor Sven Francque took place 90 minutes after the EASL Congress closed. The discussion focuses on plans and hopes for the future, both the future of MASL…
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This week, Surfing the MASH Tsunami looks back on interviews Roger Green conducted during the EASL Congress itself. This conversation with SurfingMASH co-host and Tawazun Health Founder and Clinical Director Louise Campbell took place on the last day of the Congress. This conversation centered on three major topics addressed at the EASL Congress, e…
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This week, Surfing the MASH Tsunami looks back on interviews Roger Green conducted during the EASL Congress itself. This conversation with SurfingMASH co-host and Tawazun Health Founder and Clinical Director Louise Campbell took place on the first day of the Congress. Roger's first interview with Louise took place at the end of Thursday, the openin…
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This week, Surfing the MASH Tsunami looks back on interviews Roger Green conducted during the EASL Congress itself. This conversation with Fatty Liver Alliance Founder and CEO Mike Betel took place Wednesday of Congress week, a day for special sections and industry presentations, but one day before the General Session opened. The first part of the …
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This week’s vault comes from our first episode with Shira Zelber-Sagi. She and Ken Cusi joined us during US Thanksgiving Week 2022 to discuss nutrition and behavioral issues related to MASLD. The episode’s original writeup explains: Surfing the MASH Tsunami hosts its first episode dedicated to nutrition and NASH with distinguished guest, Prof. Shir…
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Co-chairs Shira Zelber-Sagi and Mike Betel and panelists Tom Marjot and José Willemse, all from the EASL Congress session "Patient Experiences in Clinical Settings," join Louise Campbell to the need for resources that allow MASLD patients to access shared experience programs and holistic MASLD support programs. This final conversation focuses on sh…
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Co-chairs Shira Zelber-Sagi and Mike Betel and panelists Tom Marjot and José Willemse, all from the EASL Congress session "Patient Experiences in Clinical Settings," join Louise Campbell to discuss ways that socioeconomic and psychological issues impact the dynamic of the physician-patient consult, and, as a result, often patient adherence to thera…
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Co-chairs Shira Zelber-Sagi and Mike Betel and panelists Tom Marjot and José Willemse, all from the EASL Congress session "Patient Experiences in Clinical Settings," join Louise Campbell to discuss strategies and questioning styles that can improve the dynamic of the physician-patient consult. This conversation starts with Tom stating that having m…
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Co-chairs Shira Zelber-Sagi and Mike Betel and panelists Tom Marjot and José Willemse, all from the EASL Congress session "Patient Experiences in Clinical Settings," join Louise Campbell to discuss some of the key dynamics shaping the physician-patient consult. This conversation starts with Mike asking Tom whether he reviews the patient's history b…
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Co-chairs Shira Zelber-Sagi and Mike Betel and panelists Tom Marjot and José Willemse, all from the EASL Congress session "Patient Experiences in Clinical Settings," join Louise Campbell to provide an overview of issues in physician-patient communication. The conversation itself has two elements. It starts with first-time surfers Tom Marjot and Jos…
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00:00:00 - Surf's Up: Season 5 Episode 23 During SurfingMASH's wrap-up interviews from the EASL Congress (S5 E19), Louise Campbell and Mike Betel mentioned a session Mike co-chaired on challenges in provider-patient communications. Today, the other co-chair, Shira Zelber-Sagi and panelists Tom Marjot and Jose Willemse join Louise and Mike to return…
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In this week's episode, Jeff Lazarus discusses the idea that the MASH community, including patient advocates, live in a "bit of a bubble," where the clinicians with whom they interact are part of the MASH community. Last year's ICER Public Comments session exposed them to an FDA Advisory Board of hepatologists...and it was a very different experien…
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In this closing conversation, Healthy Livers, Healthy Lives Chair Jeff Lazarus and Surfers Jörn Schattenberg, Louise Campbell and Roger Green discuss the upcoming United Nations General Assembly side event and consider ways listeners can support the "Healthy LIvers, Healthy Lives" coalition. Jeff discussed this impact on global care when the World …
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Healthy Livers, Healthy Lives Chair Jeff Lazarus joins Jörn Schattenberg, Louise Campbell and Roger Green to discuss the value of the updated EASL/EASD/EASO MASLD clinical practice guidelines and consider the role of Big Data in early MASLD screening. Roger asks Jeff whether he considers the updated MASLD CPG a step forward. Jeff praises the guidel…
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Healthy Livers, Healthy Lives Chair Jeff Lazarus joins Jörn Schattenberg, Louise Campbell and Roger Green to discuss some of the specific structural challenges that confront global MASLD public policy, along with some promising local activities. Louise observes that, in her experience, primary care practitioners appreciate the support that speciali…
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Healthy Livers, Healthy Lives Chair Jeff Lazarus joins Jörn Schattenberg, Louise Campbell and Roger Green to discuss why political will is so important in overcoming inertia and obstruction in global MASLD public health policy. Louise notes that she left NHS because of obstruction against earlier stage efforts to promote liver health and asks how t…
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Healthy Livers, Healthy Lives Chair Jeff Lazarus joins Jörn Schattenberg, Louise Campbell and Roger Green to discuss how the coalition came into existence and to describe two initiatves aimed at increasing early screening. Jeff starts the conversation by describing the "bit of a bubble" in which the MASLD community lives: great news and lots of exc…
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Dave Winterling is one of the biggest experts on the Mt. Hood Ski Patrol. He has been a patroller for 8 seasons, been the Chief Patroller, and is currently serving as the President of the Mt. Hood Ski Patrol. He joins us today for some skiing and a two part interview about the Mt. Hood Ski Patrol. Please donate to the Mt. Hood Ski Patrol at https:/…
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00:00:00 - Surf's Up: Season 5 Episode 22 Jeff Lazarus joins Jörn Schattenberg, Louise Campbell and Roger Green to discuss Healthy Livers, Healthy Lives, a coalition of four major professional organizations (AASLD, ALEH, APASL and EASL) and other partners. This coalition works with other specialties to create global public health awareness and driv…
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This week's vault conversation looks back 17 months when Ken Cusi joined co-hosts Louise Campbell, Jörn Schatenberg and Roger Green to discuss the revised AASLD Practice Guidance that had been issued the previous week. At the time, here was SurfingMASH's summary of the conversation: Late last week, AASLD published new practice guidance on the clini…
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In this closing conversation, updated MASLD CPG co-authors Frank Tacke and Elisabetta Bugianesi and podcast co-hosts Louise Campbell and Roger Green consider what the guidelines might foretell in changes in provider education, structure of patient visits and treatment in less affluent or medically advanced countries. The last set of questions begin…
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For most of this conversation, updated MASLD CPG co-authors Frank Tacke and Elisabetta Bugianesi discuss key issues related to pharmacology and prescribing choices. At the end, the focus shifts to the guidelines' overall benefits and some new kinds of education they call for. The conversation starts with co-host Roger Green asking about key issues …
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In this conversation, updated MASLD CPG co-authors Frank Tacke and Elisabetta Bugianesi discuss some of the guidelines' key goals and issues surrounding the screening, diagnosis and management of MASLD patients. As the conversation starts, co-host Roger Green says that he, too, was impressed that all these adjustments were made within a month at th…
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In this conversation, updated MASLD CPG co-authors Frank Tacke and Elisabetta Bugianesi explain how the guidelines process benefitted from the close collaboration between EASL, EASD, and EASO. The conversation starts with Elisabetta conveying the "big advantage" that came from this collaboration. The presence of the three organizations conveyed the…
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Two of the co-authors of the upgraded MASLD Clinical Practice Guidelines, Elisabetta Bugianesi and Frank Tacke join Louise Campbell and Roger Green to discuss the guidelines. The theme for the conversation is "introductions". First, the audience is introduced to co-authors Elisabetta Bugianesi and Frank Tacke, neither of whom has Surfed the Tsunami…
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00:00:00 - Surf's Up: Season 5 Episode 21 One important session at the EASL Congress 2024 involved the presentation of the new MASLD Clinical Practice Guidelines. CPG co-authors Elisabetta Bugianesi and Frank Tacke join Louise Campbell and Roger Green to share their perspectives on the guidelines' development some key recommendations. 00:09:36 - Re…
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In this conversation from July 2023, Stephen Harrison, Jörn Schattenberg and Roger Green discuss the implications of presentations on the FGF-21 agent efruxifermin and the dual GLP/glucagon agonists pemvidutide and efinopegdutide. Here is the description Roger wrote for the original conversation: In this session, conversation shifts from resmetirom…
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Mazen Noureddin and Naim Alkhouri join Jörn Schattenberg and Roger Green to discuss some of the other major drug development stories from the EASL Congress 2024, with special focus on denifenstat, ION-224 and TAK-227, and to review the SPECIAL study on bariatric surgery and cirrhosis. The panelists concur that all three of these agents have potenti…
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Mazen Noureddin and Naim Alkhouri join Jörn Schattenberg and Roger Green to focus on the role FGF-21s will play in long-term advanced fibrosis treatment: induction or long-term therapy...or might we even think of the class as being able to produce a "MASH cure?" Responding to Naim's comment closing the previous discussion, Mazen questions why we re…
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Naim Alkhouri and Mazen Noureddin join Jörn Schattenberg and Roger Green to discuss issues regarding incretin agonists and results from the efruxiermin late-breaker at the EASL Congress 2024. Naim shares his general excitement about glucagon agents in general. He mentions that the efinopegdutide study included a semaglutide cell, which showed furth…
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Mazen Noureddin and Naim Alkhouri join Jörn Schattenberg and Roger Green to discuss the tirzepatide late-breaker at the EASL Congress 2024 and other "Twin-cretins," all of which are GLP-glucagon combinations. "Twin-cretins" is the name Jörn has coined for agents with a GLP-1 agonist plus another incretin effect. Tirzepatide is a GLP/GIP agent, whil…
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Naim Alkhouri and Mazen Noureddin join Jörn Schattenberg and Roger Green to discuss some of the new research on resmetirom at the EASL Congress 2024. Mazen begins this discussion by covering a paper he presented on Stephen's behalf, looking at dose-response with resmetirom. The analysis indicated that PDFF and histology improvements at the 100mg do…
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Summary: In this episode, Gene Fay interviews Jeff Hudesman, CISO at Pinwheel, about his career in cybersecurity. Jeff shares his journey from starting as an intern at Memorial Sloan Kettering Cancer Center to working at Sony and eventually joining Pinwheel. He discusses the differences between working in large companies like Sony and startups, hig…
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00:00:00 Surf's Up, Season 5 Episode 20 Naim Alkhouri and Mazen Noureddin join co-hosts Jörn Schattenberg and Roger Green to discuss major drug development stories from the EASL Congress 2024. They pay tribute to Stephen Harrison and proceed to groundbreakers. 00:08:16 - Presentations on Resmetirom Mazen shares a paper he presented looking at resme…
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