Conversations covering the Manufacturing sector focussed on the Cambridgeshire and Peterborough Region.
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Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists
David Brühlmann: Biotech Entrepreneur & Cell Culture Technology Innovation Aficionado
The Go-to Podcast for Biotech Scientists Who Want to Master Bioprocess CMC Development and Manufacturing of Biologics. **TOP 10 LIFE SCIENCES PODCAST** Do you want to simplify bioprocessing so that you can scale with confidence and reduce time to market? Are you sick of feeling overwhelmed by the complexity and guesswork of biologics drug development? Do you wish you had more time to enjoy the beauty of science, without worrying about failing your cell culture process development and commerc ...
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65: Freezing and Thawing Cells: the Science Behind Cryopreservation w/ Mark Davison - Part 1
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Picture a world where we can freeze cells and bring them back to life perfectly intact. In this episode, we're joined by Mark Davison, a leading expert in cryopreservation and CEO of Grant Instruments to uncover the intricate science of freezing and thawing cells. From basic principles to advanced techniques, we delve into how cryopreservation is r…
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64: Why Sound Waves Are the Future of Gene Therapy Bioreactors w/ Gabriel Dumy - Part 2
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Could sound waves be the revolutionary key to gene therapy manufacturing? In this episode, Gabriel Dumy, CTO and Co-founder at Kolibri, reveals how acoustic waves are set to transform cell harvesting and gene transfection processes, making biomanufacturing more efficient and less damaging to cells. Kolibri is a company revolutionizing the way we gr…
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63: Why Sound Waves Are the Future of Gene Therapy Bioreactors w/ Gabriel Dumy - Part 1
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Are sound waves the key to revolutionizing gene therapy? In this groundbreaking episode, we sit down with Gabriel Dumy, CTO and Co-founder at Kolibri, a company revolutionizing the way we grow and engineer cells at scale using acoustic waves. Gabriel shares the challenges facing modern bioproduction and unveils an exciting solution that's setting t…
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62: Magnetic Bead Technology: The New Era in Downstream Processing w/ Nils Brechmann - Part 2
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Dive into the future of bioprocessing with Nils Brechmann, Marketing Manager at MAGic BioProcessing and co-inventor of the process applications, as we explore how magnetic bead technology is transforming downstream processing. MAGic BioProcessing is a biotech company from Uppsala, Sweden, that develops magnetic-based recovery of biologicals. Key Ta…
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61: Magnetic Bead Technology: The New Era in Downstream Processing w/ Nils Brechmann - Part 1
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Dive into the latest episode as we explore how magnetic bead technology is revolutionizing downstream processing, promising higher yields and greater purity. Our guest, Nils Brechmann, Marketing Manager at MAGic BioProcessing and co-inventor of the process applications, shares his insights on overcoming industry challenges and the future of purific…
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60: Next-Generation Sequencing: Transforming Science and Medicine w/ Jonathon Hill - Part 2
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Unlock the future of epigenetics and join us for an insightful conversation with Jonathon Hill as he delves into the groundbreaking world of next-generation sequencing (NGS) and its transformative impact on science and medicine. Jonathon Hill is the VP of Science and Technology and a co-founder of Wasatch BioLabs and Associate Professor of Cell Bio…
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59: Next-Generation Sequencing: Transforming Science and Medicine w/ Jonathon Hill - Part 1
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Curious about the latest advancements in next-generation sequencing (NGS) and how they are revolutionizing science and medicine? In this episode, we delve into the cutting-edge developments of NGS with our expert guest, Jonathon Hill, VP of Science and Technology and a co-founder of Wasatch BioLabs and Associate Professor of Cell Biology and Physio…
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58: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls w/ Matthias Müllner - Part 2
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Dive into the realm of biotech with our latest episode as we unravel the enigma of Quality by Design (QbD) with Matthias Müllner, CEO of & Co-Founder bespark*bio, a company empowering viral vector-based medicines. Discover how integrating QbD principles early in your development cycle can revolutionize your approach to producing safe, high-quality …
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57: Crafting a Solid CMC Strategy: Key Factors and Common Pitfalls w/ Matthias Müllner - Part 1
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Join us for an insightful episode as we dive into the world of bioprocess CMC development strategies with Matthias Müllner, CEO of & Co-Founder bespark*bio, a company empowering viral vector-based medicines. Matthias shares his wealth of knowledge on avoiding common pitfalls in developing robust Chemistry, Manufacturing, and Controls (CMC) strategi…
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56: Cultivated Meat: A Promising Future or an Inevitable Bubble? w/ Steven Lang - Part 2
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Is cultivated meat the food of tomorrow or just a passing trend? In this episode, we dive deep with Steven Lang, an expert in the field of cultivated meat. Steven sheds light on the intricate process of creating meat in the lab, the challenges faced, and the potential future of this innovative industry. Key Takeaways: Precision in Analytics: Discov…
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55: Cultivated Meat: A Promising Future or an Inevitable Bubble? /w Steven Lang - Part 1
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How can you create an environment suitable for shear-stress-sensitive cells that results in higher cell concentrations and superior quality? Essentially, bionic bioreactors revolutionize this process, changing the game rules with their ability to facilitate bubble-free gas exchange. Join us in this episode as we unravel the groundbreaking innovatio…
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54: Bionic Bioreactors: The Key to Stress-Free Cell Cultivation w/ Patrick Bongartz - Part 2
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19:19
How can you create an environment suitable for shear-stress-sensitive cells that results in higher cell concentrations and superior quality? Essentially, bionic bioreactors revolutionize this process, changing the game rules with their ability to facilitate bubble-free gas exchange. Join us in this episode as we unravel the groundbreaking innovatio…
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53: Bionic Bioreactors: The Key to Stress-Free Cell Cultivation w/ Patrick Bongartz - Part 1
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How can you provide stress-free cultivation conditions to achieve higher cell concentrations and quality? In a nutshell, bionic bioreactors and thus change bubble-free gas exchange change the game. Join us as we delve into the future of biotech with our guest, Patrick Bongartz, CEO of BioThrust and an expert in innovative bioreactor design. Key Hig…
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52: Unraveling the Complexity of Commercializing Cell and Gene Therapies w/ Wajiha Ali - Part 2
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Does the process of commercializing cell and gene therapies seem complex and unclear to you? Dive deep into the groundbreaking world of cell and gene therapies with our guest, Wajiha Ali, a strategy expert who believes in bridging the gap between research and commercialization with data, as we unravel the complexities of bringing life-saving therap…
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51: Unraveling the Complexity of Commercializing Cell and Gene Therapies w/ Wajiha Ali - Part 1
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Are you finding the path to commercializing cell and gene therapies complex and uncertain? Join us as we explore this intricate landscape with our guest, Wajiha Ali. As a strategy expert who believes in bridging the gap between research and commericalization with data who she will guide us through the challenges, victories, and vital strategies for…
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50: Decode Bioprocess Success: The Art of Stakeholder Management - Part 2
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In the second part of "Decode Bioprocess Success: The Art of Stakeholder Management," we delve deeper into the strategies for effective stakeholder management in bioprocess development. Through a step-by-step approach, we explore how to identify, classify, and engage with stakeholders to ensure project success. Key highlights: Learn how to create a…
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49: Decode Bioprocess Success: The Art of Stakeholder Management - Part 1
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In this episode, we embark on a journey to uncover the essential strategies for navigating stakeholder relationships in bioprocess CMC development projects. We delve into the critical role of stakeholders in bioprocess development and how their engagement can determine the success or failure of a project. Drawing from real-life experiences and insi…
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48: Mastering Process Economics: Driving Down Costs in Antibody Production w/ Brian Kelley - Part 2
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Unlock the secrets to cost-efficient antibody therapeutics with Brian Kelley, Senior Vice President of Process Development at VIR Biotechnology. In this illuminating episode, industry expert Brian Kelley shares invaluable insights into driving down manufacturing costs while maintaining quality and accessibility. From optimizing batch sizes to maxim…
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47: Mastering Process Economics: Driving Down Costs in Antibody Production w/ Brian Kelley - Part 1
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Join us in this enlightening episode as we explore process economics with industry expert Brian Kelley. He is the Senior Vice President of Process Development at VIR Biotechnology. Unraveling the mysteries of cost management in antibody therapeutics, Brian sheds light on the intricate challenges faced by biotech scientists and engineers. Key Highli…
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46: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 2
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Dive into the future of food with our latest episode, "From Lab to Table: The Science Behind Cultivated Meat." With our guest, Petra Hanga, a Lecturer in Biochemical Engineering at University College London and Chief Scientific Officer of Quest Meat Ltd., we unravel the secrets behind this groundbreaking technology. Key highlights: 1. Discover how …
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45: From Lab to Table: The Science Behind Cultivated Meat w/ Petra Hanga - Part 1
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Dive into the fascinating world of cultivated meat with our guest, Petra Hanga, Lecturer in Biochemical Engineering – Cellular Agriculture at University College London and the Chief Scientific Officer of Quest Meat Ltd. In this episode, Petra sheds light on the intricacies of developing cultivated meat and reveals the key hurdles biotech scientists…
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44: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 2
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Does uncovering the secrets of glycan engineering feel like navigating a maze of molecular complexity? In this captivating continuation of our exploration into the world of glycan engineering, we delve deeper into groundbreaking innovations and the crucial role of analytics in ensuring consistent quality. Henning von Horsten, Professor of Industria…
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43: Mastering the Art and Science of Glycan Engineering in Drug Development w/ Henning von Horsten - Part 1
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Does unlocking the secrets of glycan engineering seem like navigating a labyrinth of molecular complexity? In this episode, we delve into the pivotal role of glycans as critical quality attributes (CQAs) in biotherapeutics. Henning von Horsten, Professor of Industrial Bioengineering at HTW Berlin (University of Applied Sciences in Berlin), sheds li…
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42: Revealing the Disciplined Pursuit of Less in Bioprocessing - Part 2
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Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around. Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing o…
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41: Revealing the Disciplined Pursuit of Less in Bioprocessing - Part 1
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Hey, fellow scientists! Do you find yourself buried under an avalanche of tasks, unsure which one truly matters? If you're tired of the chaos and want to reclaim control of your time and energy, stick around. Today, we're unlocking the secrets of Essentialism, tailor-made for busy biotech scientists like you. We discuss the importance of focusing o…
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40: Balancing Perfusion Process Development and Sustainability w/ Jochen Sieck - Part 2
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Explore the intricate world of perfusion and its sustainability challenges in the part 2 of this episode. Dive into the operational side of managing vast quantities of media production and storage, and discover smart strategies to address these challenges. Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science, d…
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39: Balancing Perfusion Process Development and Sustainability w/ Jochen Sieck - Part 1
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Explore perfusion processes and sustainability with our guest, Jochen Sieck, Director of Cell Culture Media and Process Development at Merck Life Science. Learn about the evolution of perfusion methodologies, its historical roots in addressing product stability, and its recent return to continuous and integrated manufacturing. Jochen discusses the …
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38: How to Master Downstream: A Deep Dive Into Bioprocessing Purification w/ Wei Zhang - Part 2
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In part 2 of this insightful episode, we embark on a journey into the intricate world of biotech purification processes. Our guest, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into three key modalities, shedding light on the challenges and advancements in virus, RNA, and traditional vaccine purification. You will …
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37: How to Master Downstream: A Deep Dive Into Bioprocessing Purification w/ Wei Zhang - Part 1
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In this episode, Wei Zhang, DSP Group Head at A*STAR Bioprocessing Technology Institute, delves into the complexities of purification. Wei’s team pioneers bioprocessing processes for diverse biotherapeutics. You will gain valuable insights into the intricate challenges and innovative solutions in bioprocessing purification. You will learn: Master s…
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36: Smart Biotech Development Strategies for Adherent Cell Culture w/ Joel Eichmann - Part 2
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Welcome back to the second part of our insightful interview with Joel Eichmann, Managing Director of Green Elephant Biotech. In this episode, we delve deeper into the technical aspects of adherent cell expansion systems, explore sustainable biotech practices, and discuss key considerations for cost-efficient and environmentally friendly bioprocessi…
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35: Smart Biotech Development Strategies for Adherent Cell Culture w/ Joel Eichmann - Part 1
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Get ready for a deep dive into the world of bioprocess development as Joel Eichmann, Managing Director of Green Elephant Biotech, shares his expertise on smart strategies for adherent cell culture . Join us as we unravel the intricacies of adherent cell culture and discover the innovative strategies shaping the future of bioprocess development. You…
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34: The 7 Habits of Highly Successful Innovators - Part 2
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Uncover the secrets of successful innovators, including Steve Jobs, Elon Musk, and Thomas Edison, in this enlightening episode of our podcast. We dive deep into the habits that set these trailblazers apart and fuel their innovative spirit. Key learnings include: The power of curiosity and how it leads to groundbreaking ideas and improvements. The i…
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33: The 7 Habits of Highly Successful Innovators - Part 1
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11:28
Uncover the secrets of successful innovators, including Steve Jobs, Elon Musk, and Thomas Edison, in this enlightening episode of our podcast. We dive deep into the habits that set these trailblazers apart and fuel their innovative spirit. Key learnings include: The power of curiosity and how it leads to groundbreaking ideas and improvements. The i…
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32: The Future of Glycoengineering: Trends Unveiled w/ Thomas Rexer - Part 2
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Discover the hurdles and breakthroughs in glycoengineering, including the high costs of activated sugars. Thomas Rexer, CTO of eversyn, a spin-off of the Max Planck Institute Magdeburg, unveils eversyn's multi-step biocatalysis process, designed to significantly drive down costs and make in vitro glycoengineering more accessible on a large scale. K…
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31: The Future of Glycoengineering: Trends Unveiled w/ Thomas Rexer - Part 1
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Get ready for a crash course in glycoengineering as Thomas Rexer, CTO of eversyn, a spin-off of the Max Planck Institute Magdeburg, breaks down the significance of modifying glycans in biopharmaceuticals. Explore the science behind glycoengineering and its potential to enhance the properties of therapeutic proteins. Key Insights: Unlock new frontie…
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30: From Monoclonals to Gene Therapy: Tips for Process Development w/ Neil Templeton - Part 2
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In our insightful second part of the conversation, we broaden our perspective to delve into the various modalities within the biotech industry, highlighting the unique and shared aspects of process development and scale-up. Neil Templeton, the Director of Upstream Process Development at Solid Biosciences, passionately articulates his commitment tow…
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29: From Monoclonals to Gene Therapy: Tips for Process Development w/ Neil Templeton - Part 1
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In this enlightening episode, we're joined by Neil Templeton, Director in Upstream Process Development at Solid Biosciences, who pulls back the curtain on the intricate world of bioprocess development and manufacturing. Neil delves into the shifting paradigms of the industry, sharing his expert insights on overcoming the unique challenges that surf…
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28: How to Simplify Project Management in Bioprocess Development - Part 2
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Tackling bioprocess development and scale-up can be complex. While the science might be challenging, project management within biotech doesn't have to be. In this engaging episode, we'll guide you on how to streamline your CMC development, demystifying the complexities of project planning and execution. Here's what you'll gain: Discover the secret …
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27: How to Simplify Project Management in Bioprocess Development - Part 1
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Bioprocess development and scale-up are complex. Science may give you headaches, but biotech project management should not. In this riveting episode, you'll learn how to simplify your CMC development, guiding you through the maze of project planning and execution. Key Takeaways: Uncover how to "Plan for Success," ensuring your projects are well-str…
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26: 9 Critical Steps for a Seamless Transition to Large-Scale Production - Part 2
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In this riveting episode of the Smart Biotech Scientist podcast, we navigate the intricate labyrinth of biotech scale-ups. We distill the process down to 9 essential steps for a smooth transition from laboratory to large-scale production. Key Insights: Acquire Comprehensive Process Understanding: Bolster your decision-making and problem-solving ski…
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25: 9 Critical Steps for a Seamless Transition to Large-Scale Production - Part 1
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In this enlightening episode of the Smart Biotech Scientist podcast, we delve into the complex world of biotech scale-ups. We break down the 9 crucial steps to ensure a seamless transition from lab to large-scale production. Top 3 Takeaways: Gain Comprehensive Process Understanding: Enhance your decision-making and problem-solving abilities by thor…
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24: Strategies for Success: Master CMC Development with Gene Lee - Part 2
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If you've ever wondered how to seamlessly transition from R&D to process development, this is your golden ticket. Uncover practical strategies and expert advice that can be your compass through the intricate landscape of mastering CMC development. Uncover the challenges and tactics to seamlessly navigate this critical phase. Conduct Early Developab…
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23: Strategies for Success: Master CMC Development with Gene Lee - Part 1
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Embark on a journey into the intricate world of CMC development with our latest episode, unraveling the challenges that often baffle biotech scientists. The complexity of CMC development is a formidable hurdle, and in this insightful discussion, we delve into strategies to master this critical process. Key Takeaways: Start Early: Learn how starting…
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22: Unleashing Effective QbD Strategies to Master Cell Therapy with Shin Kawamata - Part 2
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Are you looking for advanced strategies to enhance the quality and efficiency of cell therapy manufacturing processes? In this episode with Shin Kawamata, CEO of Cyto-Facto Inc., we dive into the transformative power of digitization in cell therapy manufacturing and explore strategies to enhance efficiency and reduce costs. Actionable Takeaways: In…
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21: Unleashing Effective QbD Strategies to Master Cell Therapy with Shin Kawamata - Part 1
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Are the escalating costs and intricate technical hurdles of cell therapy development causing you stress? Tune into this insightful podcast episode featuring Shin Kawamata, CEO of Cyto-Facto Inc. in Kobe, Japan, who shares his expertise and innovative solutions to these pressing issues in the cell therapy industry. Discover how to streamline your ma…
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20: How to Take Your Molecule From the Lab to Clinical Trials w/ Bernardo Estupiñán Gaisbauer - Part 2
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Welcome to Part 2 of our conversation with Bernardo Estupiñán Gaisbauer, Principal at Drug Biologics Consulting. In this insightful episode, we dive into the complex world of taking a molecule from the lab to clinical trials. Our guest shares invaluable insights into outsourcing strategies for biotech companies. Key Learnings: Strategic Outsourcing…
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19: How to Take Your Molecule From the Lab to Clinical Trials w/ Bernardo Estupiñán Gaisbauer - Part 1
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Are you ready to unlock the secrets of taking your molecule from the lab to clinical trials? Join us in an exclusive interview with Bernardo Estupiñán Gaisbauer, a seasoned expert and principal at Drug Biologics Consulting, as he reveals the crucial steps and strategies necessary for a successful journey in CMC development. Biotech scientists often…
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18: How Extracting Gold From Your Data Accelerates Process Development w/ Ioscani Jiménez del Val - Part 2
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In part 2 of this interview with Ioscani, Assistant Professor at the School of Chemical & Bioprocess Engineering, University College Dublin, we delve into the art and science of accelerating process development through the strategic extraction of valuable insights from data. Our guest, a seasoned expert in computational modeling, unfolds the intric…
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17: How Extracting Gold From Your Data Accelerates Process Development w/ Ioscani Jiménez del Val - Part 1
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Senarai
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Disukai
19:23
Join us as we unravel the complexities of computational methods in bioprocessing, featuring cutting-edge research on glycosylation and process development. Ioscani Jiménez del Val, Assistant Professor at the School of Chemical & Bioprocess Engineering, University College Dublin, explores the intricacies of creating computational models, closing the…
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1
16: Bacon Without Pigs? Innovations in Cultivated Meat Manufacturing with Beat Thalmann - Part 2
19:56
19:56
Main Kemudian
Main Kemudian
Senarai
Suka
Disukai
19:56
In part 2, we explore the details of cost reduction in cultivated meat manufacturing, with a focus on two important factors: media and simplified bioreactors. Beat Thalmann, a passionate innovator and serial entrepreneur specializing in the development of animal-free cell culture systems, highlights the strategic importance of selecting the right c…
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