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This study looked at whether eating meat is linked to dementia in older adults. The researchers used information from a large group of people in the UK Biobank and found that eating processed meat was associated with an increased risk of developing all-cause dementia and Alzheimer's disease. However, eating unprocessed red meat was associated with …
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My favorite floss: https://cocofloss.com/ (not an affiliate link, just a fan) Summary:Hepatitis C and herpes simplex virus 2 infections make you more likely to develop dementia. Many people have been infected with these viruses, making them important risk factors for dementia.Having many infections over your lifetime plus gum disease with certain b…
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Original study: https://www.nejm.org/doi/full/10.1056/NEJMoa1215740 This study looked at a large group of people, some with diabetes and some without, to see if there was a link between their blood sugar levels and their risk of developing dementia. They found that people with higher blood sugar levels, even those without diabetes, were more likely…
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This scoping review, titled "Diet and Anxiety: A Scoping Review," summarizes the current scientific literature on the relationship between diet and anxiety. It analyzes numerous studies, both human and animal, to assess how various dietary factors, such as the intake of specific nutrients, dietary patterns, and the gut microbiome, impact anxiety sy…
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STUDY: Vyas A, Aisopos F, Vidal ME, Garrard P, Paliouras G. Identifying the presence and severity of dementia by applying interpretable machine learning techniques on structured clinical records. BMC medical informatics and decision making. 2022 Oct 17;22(1):271.Oleh Gavin Thomas
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Information from the NIH as presented by Google's Notebook LM find the original article here: https://www.nia.nih.gov/health/alzheimers-causes-and-risk-factors/what-happens-brain-alzheimers-disease You can find me at https://instagram.com/theinevitabledanielleOleh Danielle Vincent & Google Notebook LM
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A recap of the most recent study from The Lancet Commission on dementia prevention research: https://www.thelancet.com/commissions/dementia-prevention-intervention-care?dgcid=tlcom_infographic_demetia-risks-24_lancet This podcast was made with Notebook LM You can find me at https://instagram.com/theinevitabledanielle…
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This research paper describes a multicenter randomized controlled trial called The HOME Study, which investigated the effectiveness and cost-effectiveness of a novel approach to psychiatric care called Proactive Integrated Consultation-Liaison Psychiatry (PICLP) for older medical inpatients. The study compared PICLP to usual care, and although the …
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This research investigates the relationship between changes in white matter microstructure and cognitive decline in individuals with major depressive disorder (MDD). The study follows a large cohort of participants with MDD and healthy controls over a two-year period, analyzing cognitive performance and white matter integrity using neuropsychologic…
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This research article investigates the link between amyloid beta (Aβ), a hallmark protein associated with Alzheimer's disease (AD), and ferroptosis, a type of programmed cell death. The researchers analyzed post-mortem brain tissue from individuals with AD and found that Aβ pathology is associated with changes in the expression of proteins related …
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Studies: Spector A, Thorgrimsen L, Woods BO, Royan L, Davies S, Butterworth M, Orrell M. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. The British Journal of Psychiatry. 2003 Sep;183(3):248-54. Woods B, O'Philbin L, Farrell EM, Spector AE, Orrell M. Reminiscence therapy …
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STUDY: Sattarov, R., Havers, M., Orbjörn, C. et al. Phosphorylated tau in cerebrospinal fluid-derived extracellular vesicles in Alzheimer’s disease: a pilot study. Sci Rep 14, 25419 (2024). https://doi.org/10.1038/s41598-024-75406-0 Findings: This research paper investigates the potential of extracellular vesicles (EVs), tiny membrane-bound sacs se…
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Timeline 0:00:00 Intro 0:00:34 BPSD Guidelines Intro 0:01:28 Agitation management: Non-pharmacologic & Pharmacologic 0:03:27 Psychosis management: Non-pharmacologic & Pharmacologic 0:04:22 Depression management: Non-pharmacologic & Pharmacologic 0:05:16 Anxiety management: Non-pharmacologic & Pharmacologic 0:05:45 Disinhibited Sexual expressions: B…
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STUDIES: Laws SM, Hone E, Gandy S, Martins RN. Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Journal of neurochemistry. 2003 Mar;84(6):1215-36. Roses AD, Saunders AM. APOE is a major susceptibility gene for Alzheimer's diseas…
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STUDY: Woodham, R.D., Selvaraj, S., Lajmi, N. et al. Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial. Nat Med (2024). https://doi.org/10.1038/s41591-024-03305-yOleh Gavin Thomas
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STUDIES: Rizzi L, Rosset I, Roriz-Cruz M. Global epidemiology of dementia: Alzheimer’s and vascular types. BioMed research international. 2014;2014(1):908915. Smits LL, van Harten AC, Pijnenburg YA, Koedam EL, Bouwman FH, Sistermans N, Reuling IE, Prins ND, Lemstra AW, Scheltens P, van der Flier WM. Trajectories of cognitive decline in different ty…
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STUDY: Gallego-Rudolf J, Wiesman AI, Pichet Binette A, Villeneuve S, Baillet S, PREVENT-AD Research Group. Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults. Nature Neuroscience. 2024 Sep 18:1-8.Oleh Gavin Thomas
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STUDIES: Dobson R, Patterson K, Malik R, Mandal U, Asif H, Humphreys R, Payne M, Eng O, Huzzey L, Clare A, Green K. Eligibility for antiamyloid treatment: preparing for disease-modifying therapies for Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry. 2024 May 15. Laurell AA, Venkataraman AV, Schmidt T, Montagnese M, Mueller C, S…
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STUDIES: Xue C, Kowshik SS, Lteif D, Puducheri S, Jasodanand VH, Zhou OT, Walia AS, Guney OB, Zhang JD, Pham ST, Kaliaev A. AI-based differential diagnosis of dementia etiologies on multimodal data. Nature Medicine. 2024 Jul 4:1-3. Grigas O, Maskeliunas R, Damaševičius R. Early detection of dementia using artificial intelligence and multimodal feat…
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